Table 3 MiRNAs and corresponding target genes identified in each clinical group evaluated (only miRNAs with high discriminatory power (AUC ≥0.8) were included)

Tumor size

(≥5 cm/< 5 cm)

miR-519c-3p

HIF1A, ABCG2, ELAVL1, TIMP2, PTEN, CDKN1A

LN status

let-7f-5p

KLK10, KLK6, PRDM1, IL3, CYP19A1, COPS8, GPS1, CCND1, COPS6, MYH9, SOCS3, ELF4, CCL7, AGO1, IL6, POSTN

miR-200c-3p

TUBB3, BMI1, GEMIN2, BAP1, ZEB2, ZEB1, FN1, ZFPM2, PTPN13, RNF2, RCOR3, BRD7, ACVR2B, MSN, NTRK2, ERRFI1, CCNE2, XIAP, BCL2, TIMP2, FBLN5, VEGFA, NCAM1, IKBKB, FLT1, KLF9, TBK1, PMAIP1, NTF3, LPAR1, EDNRA, RHOA, KLHL20, PTPRD, ELMO2, ERBIN, WDR37, VAC14, TCF7L1, RASSF2, HOXB5, RIN2, KLF11, SEPT7, SHC1, MYB, ETS1, DUSP1, USP25, EFNA1, RND3, DNMT3A, DNMT3B, SP1, CFL2, CDH11, SEC23A, KDR, HFE, DLC1, ATRX, ZNF217, BTC, ZFPM1, PIN1, KRAS, NOTCH1, GATA4, SUZ12, ROCK2, UBQLN1, E2F3, MALAT1, CDK2, PRKCZ, NOS3, SIRT1, FOXO1, PDCD10, ADAM12, PTEN, LEPR, CRKL, MYLK, SH3PXD2A, DNAJC3, JAZF1, RPS6KB1, SLC1A2

miR-301a-5p

PTEN, BTG1, NDRG2

miR-520d-5p

PPIB

miR-518a-5p

MCL1, PIK3C2A, CCL2

miR-580-3p

TWIST1

miR-595

PARD6A

REC status

miR-184

AKT2, INPPL1, NFATC2, SOX7, AGO2, MYC, BCL2, EZR, SND1, GAS1, ZFPM2, PDGFB, PLPP3, AKT1, BIN3, PRKCB, PPP1R13L, TNFAIP2, PKM

miR-449b-5p

SIRT1, CCNE2, MET, GMNN, HDAC1, CDC25A, CDK6, MYCN, NEAT1

miR-542-3p

BIRC5, ILK, MTDH, PIM1, AKT1, BMP7, RPS23, ANGPT2, OTUB1, IGFBP1, CTTN, PIK3R1, FZD7

miR-593-3p

CDC274, PROP1

miR-595

PARD6A