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Table 4 Associations between ERCC1 and ERCC2 gene haplotypes and Quality of Life, depression and anxiety (unadjusted and adjusted for Environmental factors)

From: Genetic polymorphisms and haplotypes of ERCC1 and ERCC2 associated with quality of life, depression, and anxiety status among patients with lung cancer

Area

Gene

SNPs

Haplotype

P

Beta (95%CI)a or

OR (95%CI)b

Environmental factors correction

P

Beta (95%CI)a or

OR (95%CI)b

C30 Cognitive functions

ERCC1

rs762562-rs3212986

AA

0.038

−4.87 (− 9.45--0.29)

0.029

− 5.34 (− 10.13--0.56)

  

AC

0.058

4.66 (−0.14–9.47)

0.083

4.47 (− 0.56–9.50)

  

GC (ref)

–

–

–

–

C30 Physical functions

ERCC1

rs762562-rs3212986

AA

0.019

−5.33 (−9.75--0.90)

0.014

− 5.89 (−10.53--1.25)

  

AC

0.239

2.77 (−1.83–7.38)

0.202

3.22 (−1.71–8.14)

  

GC (ref)

–

–

–

–

LC13 Dysphagia

ERCC1

rs762562-rs3212986

AA

0.165

1.80 (0.79–4.10)

0.044

3.32 (1.03–10.66)

  

AC

0.063

0.31 (0.09–1.06)

0.133

0.33 (0.08–1.40)

  

GC (ref)

–

–

–

–

C30 Emotional functions

ERCC1

rs3212986-rs11615

AG

0.490

−1.52 (−5.83–2.79)

0.490

−1.59 (−6.12–2.93)

  

CA

0.007

6.04 (1.72–10.36)

0.005

6.61 (2.08–11.15)

  

CG (ref)

–

–

–

–

C30 Cognitive functions

ERCC1

rs3212986-rs11615

AG

0.027

−5.27 (−9.90--0.63)

0.028

−5.42 (− 10.24--0.60)

  

CA

0.075

4.38 (−0.43–9.19)

0.060

4.77 (−0.18–9.72)

  

CG (ref)

–

–

–

–

C30 Physical functions

ERCC1

rs3212986-rs11615

AG

0.009

−6.06 (−10.55--1.57)

0.007

−6.55 (− 11.24--1.86)

  

CA

0.178

3.17 (−1.43–7.77)

0.125

3.80 (−1.04–8.65)

  

CG (ref)

–

–

–

–

C30 Appetite loss

ERCC1

rs3212986-rs11615

AG

0.037

1.57 (1.03–2.40)

0.025

1.67 (1.07–2.61)

  

CA

0.708

1.09 (0.70–1.68)

0.956

0.99 (0.62–1.57)

  

CG (ref)

–

–

–

–

LC13 Dysphagia

ERCC1

rs3212986-rs11615

AG

0.068

2.18 (0.94–5.05)

0.019

4.43 (1.28–15.39)

  

CA

0.027

0.19 (0.04–0.82)

0.035

0.17 (0.032–0.88)

  

CG (ref)

–

–

–

–

SAS Anxiety standard score

ERCC1

rs3212986-rs11615

AG

0.130

1.34 (−0.39–3.07)

0.076

1.63 (−0.16–3.41)

  

CA

0.014

−2.25 (−4.02- -0.47)

0.023

−2.18 (−4.05- -0.32)

  

CG (ref)

–

–

–

–

C30 Emotional functions

ERCC2

rs13181-rs3916874-rs238416

GCC

0.047

6.81 (0.125–13.50)

0.035

7.60 (0.60–14.61)

  

TCC

0.411

−1.75 (−5.91–2.42)

0.248

−2.60 (−7.00–1.80)

  

TGC

0.199

3.17 (− 1.66–8.01)

0.124

4.00 (− 1.08–9.09)

  

TCT (ref)

–

–

–

–

LC13 Chest pain

ERCC2

rs13181-rs3916874-rs238416

GCC

0.899

0.95 (0.45–2.03)

0.712

1.18 (0.50–2.77)

  

TCC

0.705

1.09 (0.69–1.74)

0.736

1.10 (0.64–1.86)

  

TGC

0.018

0.44 (0.22–0.87)

0.020

0.42 (0.21–0.87)

  

TCT (ref)

–

–

–

–

LC13 Pain in other parts

ERCC2

rs13181-rs3916874-rs238416

GCC

0.367

0.66 (0.27–1.61)

0.198

0.52 (0.19–1.41)

  

TCC

0.042

1.59 (1.02–2.50)

0.014

1.88 (1.14–3.12)

  

TGC

0.093

0.57 (0.29–1.10)

0.145

0.58 (0.28–1.21)

  

TCT (ref)

–

–

–

–

LC13 Dysphagia

ERCC2

rs13181-rs3916874-rs238416

GCC

0.491

0.49 (0.06–3.73)

0.546

0.44 (0.03–6.32)

  

TCC

0.062

2.10 (0.96–4.55)

0.048

2.82 (1.01–7.85)

  

TGC

0.758

1.18 (0.42–3.33)

0.451

0.60 (0.16–2.28)

  

TCT (ref)

–

–

–

–

SAS Anxiety state

ERCC2

rs13181-rs3916874-rs238416

GCC

0.018

0.28 (0.10–0.80)

0.009

0.23 (0.08–0.69)

  

TCC

0.401

1.20 (0.79–1.81)

0.479

1.18 (0.75–1.85)

  

TGC

0.188

0.70 (0.41–1.19)

0.211

0.69 (0.39–1.23)

  

TCT (ref)

–

–

–

–

  1. Covariates refer to environmental factors including:sex, age, occupation, marriage, education, number of children, smoking history, drinking history, medical insurance, pathological types, clinical stages, metastasis, concurrent symptoms, operation history, and chemotherapy
  2. When calculating the frequency, the molecule = the corresponding haplotype number, the denominator of the reference haplotype = 2 * (the sample number that contains the reference haplotype), the denominator of none reference haplotype = 2 * (the sample number that contains the reference and the current haplotypes). * means multiplication
  3. aβ and 95% confidence interval (CI) were reported (Linear regression was used for general health condition and functioning domains, anxiety and depression). bodds ratio (OR) and 95% CI were reported (Logistic regression was used for symptoms domains, anxiety and depression)