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Table 4 Associations between ERCC1 and ERCC2 gene haplotypes and Quality of Life, depression and anxiety (unadjusted and adjusted for Environmental factors)

From: Genetic polymorphisms and haplotypes of ERCC1 and ERCC2 associated with quality of life, depression, and anxiety status among patients with lung cancer

Area

Gene

SNPs

Haplotype

P

Beta (95%CI)a or

OR (95%CI)b

Environmental factors correction

P

Beta (95%CI)a or

OR (95%CI)b

C30 Cognitive functions

ERCC1

rs762562-rs3212986

AA

0.038

−4.87 (− 9.45--0.29)

0.029

− 5.34 (− 10.13--0.56)

  

AC

0.058

4.66 (−0.14–9.47)

0.083

4.47 (− 0.56–9.50)

  

GC (ref)

C30 Physical functions

ERCC1

rs762562-rs3212986

AA

0.019

−5.33 (−9.75--0.90)

0.014

− 5.89 (−10.53--1.25)

  

AC

0.239

2.77 (−1.83–7.38)

0.202

3.22 (−1.71–8.14)

  

GC (ref)

LC13 Dysphagia

ERCC1

rs762562-rs3212986

AA

0.165

1.80 (0.79–4.10)

0.044

3.32 (1.03–10.66)

  

AC

0.063

0.31 (0.09–1.06)

0.133

0.33 (0.08–1.40)

  

GC (ref)

C30 Emotional functions

ERCC1

rs3212986-rs11615

AG

0.490

−1.52 (−5.83–2.79)

0.490

−1.59 (−6.12–2.93)

  

CA

0.007

6.04 (1.72–10.36)

0.005

6.61 (2.08–11.15)

  

CG (ref)

C30 Cognitive functions

ERCC1

rs3212986-rs11615

AG

0.027

−5.27 (−9.90--0.63)

0.028

−5.42 (− 10.24--0.60)

  

CA

0.075

4.38 (−0.43–9.19)

0.060

4.77 (−0.18–9.72)

  

CG (ref)

C30 Physical functions

ERCC1

rs3212986-rs11615

AG

0.009

−6.06 (−10.55--1.57)

0.007

−6.55 (− 11.24--1.86)

  

CA

0.178

3.17 (−1.43–7.77)

0.125

3.80 (−1.04–8.65)

  

CG (ref)

C30 Appetite loss

ERCC1

rs3212986-rs11615

AG

0.037

1.57 (1.03–2.40)

0.025

1.67 (1.07–2.61)

  

CA

0.708

1.09 (0.70–1.68)

0.956

0.99 (0.62–1.57)

  

CG (ref)

LC13 Dysphagia

ERCC1

rs3212986-rs11615

AG

0.068

2.18 (0.94–5.05)

0.019

4.43 (1.28–15.39)

  

CA

0.027

0.19 (0.04–0.82)

0.035

0.17 (0.032–0.88)

  

CG (ref)

SAS Anxiety standard score

ERCC1

rs3212986-rs11615

AG

0.130

1.34 (−0.39–3.07)

0.076

1.63 (−0.16–3.41)

  

CA

0.014

−2.25 (−4.02- -0.47)

0.023

−2.18 (−4.05- -0.32)

  

CG (ref)

C30 Emotional functions

ERCC2

rs13181-rs3916874-rs238416

GCC

0.047

6.81 (0.125–13.50)

0.035

7.60 (0.60–14.61)

  

TCC

0.411

−1.75 (−5.91–2.42)

0.248

−2.60 (−7.00–1.80)

  

TGC

0.199

3.17 (− 1.66–8.01)

0.124

4.00 (− 1.08–9.09)

  

TCT (ref)

LC13 Chest pain

ERCC2

rs13181-rs3916874-rs238416

GCC

0.899

0.95 (0.45–2.03)

0.712

1.18 (0.50–2.77)

  

TCC

0.705

1.09 (0.69–1.74)

0.736

1.10 (0.64–1.86)

  

TGC

0.018

0.44 (0.22–0.87)

0.020

0.42 (0.21–0.87)

  

TCT (ref)

LC13 Pain in other parts

ERCC2

rs13181-rs3916874-rs238416

GCC

0.367

0.66 (0.27–1.61)

0.198

0.52 (0.19–1.41)

  

TCC

0.042

1.59 (1.02–2.50)

0.014

1.88 (1.14–3.12)

  

TGC

0.093

0.57 (0.29–1.10)

0.145

0.58 (0.28–1.21)

  

TCT (ref)

LC13 Dysphagia

ERCC2

rs13181-rs3916874-rs238416

GCC

0.491

0.49 (0.06–3.73)

0.546

0.44 (0.03–6.32)

  

TCC

0.062

2.10 (0.96–4.55)

0.048

2.82 (1.01–7.85)

  

TGC

0.758

1.18 (0.42–3.33)

0.451

0.60 (0.16–2.28)

  

TCT (ref)

SAS Anxiety state

ERCC2

rs13181-rs3916874-rs238416

GCC

0.018

0.28 (0.10–0.80)

0.009

0.23 (0.08–0.69)

  

TCC

0.401

1.20 (0.79–1.81)

0.479

1.18 (0.75–1.85)

  

TGC

0.188

0.70 (0.41–1.19)

0.211

0.69 (0.39–1.23)

  

TCT (ref)

  1. Covariates refer to environmental factors including:sex, age, occupation, marriage, education, number of children, smoking history, drinking history, medical insurance, pathological types, clinical stages, metastasis, concurrent symptoms, operation history, and chemotherapy
  2. When calculating the frequency, the molecule = the corresponding haplotype number, the denominator of the reference haplotype = 2 * (the sample number that contains the reference haplotype), the denominator of none reference haplotype = 2 * (the sample number that contains the reference and the current haplotypes). * means multiplication
  3. aβ and 95% confidence interval (CI) were reported (Linear regression was used for general health condition and functioning domains, anxiety and depression). bodds ratio (OR) and 95% CI were reported (Logistic regression was used for symptoms domains, anxiety and depression)