Area | Gene | SNPs | Haplotype | P | Beta (95%CI)a or OR (95%CI)b | Environmental factors correction | |
---|---|---|---|---|---|---|---|
P | Beta (95%CI)a or OR (95%CI)b | ||||||
C30 Cognitive functions | ERCC1 | rs762562-rs3212986 | AA | 0.038 | −4.87 (− 9.45--0.29) | 0.029 | − 5.34 (− 10.13--0.56) |
 |  | AC | 0.058 | 4.66 (−0.14–9.47) | 0.083 | 4.47 (− 0.56–9.50) | |
 |  | GC (ref) | – | – | – | – | |
C30 Physical functions | ERCC1 | rs762562-rs3212986 | AA | 0.019 | −5.33 (−9.75--0.90) | 0.014 | − 5.89 (−10.53--1.25) |
 |  | AC | 0.239 | 2.77 (−1.83–7.38) | 0.202 | 3.22 (−1.71–8.14) | |
 |  | GC (ref) | – | – | – | – | |
LC13 Dysphagia | ERCC1 | rs762562-rs3212986 | AA | 0.165 | 1.80 (0.79–4.10) | 0.044 | 3.32 (1.03–10.66) |
 |  | AC | 0.063 | 0.31 (0.09–1.06) | 0.133 | 0.33 (0.08–1.40) | |
 |  | GC (ref) | – | – | – | – | |
C30 Emotional functions | ERCC1 | rs3212986-rs11615 | AG | 0.490 | −1.52 (−5.83–2.79) | 0.490 | −1.59 (−6.12–2.93) |
 |  | CA | 0.007 | 6.04 (1.72–10.36) | 0.005 | 6.61 (2.08–11.15) | |
 |  | CG (ref) | – | – | – | – | |
C30 Cognitive functions | ERCC1 | rs3212986-rs11615 | AG | 0.027 | −5.27 (−9.90--0.63) | 0.028 | −5.42 (− 10.24--0.60) |
 |  | CA | 0.075 | 4.38 (−0.43–9.19) | 0.060 | 4.77 (−0.18–9.72) | |
 |  | CG (ref) | – | – | – | – | |
C30 Physical functions | ERCC1 | rs3212986-rs11615 | AG | 0.009 | −6.06 (−10.55--1.57) | 0.007 | −6.55 (− 11.24--1.86) |
 |  | CA | 0.178 | 3.17 (−1.43–7.77) | 0.125 | 3.80 (−1.04–8.65) | |
 |  | CG (ref) | – | – | – | – | |
C30 Appetite loss | ERCC1 | rs3212986-rs11615 | AG | 0.037 | 1.57 (1.03–2.40) | 0.025 | 1.67 (1.07–2.61) |
 |  | CA | 0.708 | 1.09 (0.70–1.68) | 0.956 | 0.99 (0.62–1.57) | |
 |  | CG (ref) | – | – | – | – | |
LC13 Dysphagia | ERCC1 | rs3212986-rs11615 | AG | 0.068 | 2.18 (0.94–5.05) | 0.019 | 4.43 (1.28–15.39) |
 |  | CA | 0.027 | 0.19 (0.04–0.82) | 0.035 | 0.17 (0.032–0.88) | |
 |  | CG (ref) | – | – | – | – | |
SAS Anxiety standard score | ERCC1 | rs3212986-rs11615 | AG | 0.130 | 1.34 (−0.39–3.07) | 0.076 | 1.63 (−0.16–3.41) |
 |  | CA | 0.014 | −2.25 (−4.02- -0.47) | 0.023 | −2.18 (−4.05- -0.32) | |
 |  | CG (ref) | – | – | – | – | |
C30 Emotional functions | ERCC2 | rs13181-rs3916874-rs238416 | GCC | 0.047 | 6.81 (0.125–13.50) | 0.035 | 7.60 (0.60–14.61) |
 |  | TCC | 0.411 | −1.75 (−5.91–2.42) | 0.248 | −2.60 (−7.00–1.80) | |
 |  | TGC | 0.199 | 3.17 (− 1.66–8.01) | 0.124 | 4.00 (− 1.08–9.09) | |
 |  | TCT (ref) | – | – | – | – | |
LC13 Chest pain | ERCC2 | rs13181-rs3916874-rs238416 | GCC | 0.899 | 0.95 (0.45–2.03) | 0.712 | 1.18 (0.50–2.77) |
 |  | TCC | 0.705 | 1.09 (0.69–1.74) | 0.736 | 1.10 (0.64–1.86) | |
 |  | TGC | 0.018 | 0.44 (0.22–0.87) | 0.020 | 0.42 (0.21–0.87) | |
 |  | TCT (ref) | – | – | – | – | |
LC13 Pain in other parts | ERCC2 | rs13181-rs3916874-rs238416 | GCC | 0.367 | 0.66 (0.27–1.61) | 0.198 | 0.52 (0.19–1.41) |
 |  | TCC | 0.042 | 1.59 (1.02–2.50) | 0.014 | 1.88 (1.14–3.12) | |
 |  | TGC | 0.093 | 0.57 (0.29–1.10) | 0.145 | 0.58 (0.28–1.21) | |
 |  | TCT (ref) | – | – | – | – | |
LC13 Dysphagia | ERCC2 | rs13181-rs3916874-rs238416 | GCC | 0.491 | 0.49 (0.06–3.73) | 0.546 | 0.44 (0.03–6.32) |
 |  | TCC | 0.062 | 2.10 (0.96–4.55) | 0.048 | 2.82 (1.01–7.85) | |
 |  | TGC | 0.758 | 1.18 (0.42–3.33) | 0.451 | 0.60 (0.16–2.28) | |
 |  | TCT (ref) | – | – | – | – | |
SAS Anxiety state | ERCC2 | rs13181-rs3916874-rs238416 | GCC | 0.018 | 0.28 (0.10–0.80) | 0.009 | 0.23 (0.08–0.69) |
 |  | TCC | 0.401 | 1.20 (0.79–1.81) | 0.479 | 1.18 (0.75–1.85) | |
 |  | TGC | 0.188 | 0.70 (0.41–1.19) | 0.211 | 0.69 (0.39–1.23) | |
 |  | TCT (ref) | – | – | – | – |