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Table 4 Associations between ERCC1 and ERCC2 gene haplotypes and Quality of Life, depression and anxiety (unadjusted and adjusted for Environmental factors)

From: Genetic polymorphisms and haplotypes of ERCC1 and ERCC2 associated with quality of life, depression, and anxiety status among patients with lung cancer

Area Gene SNPs Haplotype P Beta (95%CI)a or
OR (95%CI)b
Environmental factors correction
P Beta (95%CI)a or
OR (95%CI)b
C30 Cognitive functions ERCC1 rs762562-rs3212986 AA 0.038 −4.87 (− 9.45--0.29) 0.029 − 5.34 (− 10.13--0.56)
   AC 0.058 4.66 (−0.14–9.47) 0.083 4.47 (− 0.56–9.50)
   GC (ref)
C30 Physical functions ERCC1 rs762562-rs3212986 AA 0.019 −5.33 (−9.75--0.90) 0.014 − 5.89 (−10.53--1.25)
   AC 0.239 2.77 (−1.83–7.38) 0.202 3.22 (−1.71–8.14)
   GC (ref)
LC13 Dysphagia ERCC1 rs762562-rs3212986 AA 0.165 1.80 (0.79–4.10) 0.044 3.32 (1.03–10.66)
   AC 0.063 0.31 (0.09–1.06) 0.133 0.33 (0.08–1.40)
   GC (ref)
C30 Emotional functions ERCC1 rs3212986-rs11615 AG 0.490 −1.52 (−5.83–2.79) 0.490 −1.59 (−6.12–2.93)
   CA 0.007 6.04 (1.72–10.36) 0.005 6.61 (2.08–11.15)
   CG (ref)
C30 Cognitive functions ERCC1 rs3212986-rs11615 AG 0.027 −5.27 (−9.90--0.63) 0.028 −5.42 (− 10.24--0.60)
   CA 0.075 4.38 (−0.43–9.19) 0.060 4.77 (−0.18–9.72)
   CG (ref)
C30 Physical functions ERCC1 rs3212986-rs11615 AG 0.009 −6.06 (−10.55--1.57) 0.007 −6.55 (− 11.24--1.86)
   CA 0.178 3.17 (−1.43–7.77) 0.125 3.80 (−1.04–8.65)
   CG (ref)
C30 Appetite loss ERCC1 rs3212986-rs11615 AG 0.037 1.57 (1.03–2.40) 0.025 1.67 (1.07–2.61)
   CA 0.708 1.09 (0.70–1.68) 0.956 0.99 (0.62–1.57)
   CG (ref)
LC13 Dysphagia ERCC1 rs3212986-rs11615 AG 0.068 2.18 (0.94–5.05) 0.019 4.43 (1.28–15.39)
   CA 0.027 0.19 (0.04–0.82) 0.035 0.17 (0.032–0.88)
   CG (ref)
SAS Anxiety standard score ERCC1 rs3212986-rs11615 AG 0.130 1.34 (−0.39–3.07) 0.076 1.63 (−0.16–3.41)
   CA 0.014 −2.25 (−4.02- -0.47) 0.023 −2.18 (−4.05- -0.32)
   CG (ref)
C30 Emotional functions ERCC2 rs13181-rs3916874-rs238416 GCC 0.047 6.81 (0.125–13.50) 0.035 7.60 (0.60–14.61)
   TCC 0.411 −1.75 (−5.91–2.42) 0.248 −2.60 (−7.00–1.80)
   TGC 0.199 3.17 (− 1.66–8.01) 0.124 4.00 (− 1.08–9.09)
   TCT (ref)
LC13 Chest pain ERCC2 rs13181-rs3916874-rs238416 GCC 0.899 0.95 (0.45–2.03) 0.712 1.18 (0.50–2.77)
   TCC 0.705 1.09 (0.69–1.74) 0.736 1.10 (0.64–1.86)
   TGC 0.018 0.44 (0.22–0.87) 0.020 0.42 (0.21–0.87)
   TCT (ref)
LC13 Pain in other parts ERCC2 rs13181-rs3916874-rs238416 GCC 0.367 0.66 (0.27–1.61) 0.198 0.52 (0.19–1.41)
   TCC 0.042 1.59 (1.02–2.50) 0.014 1.88 (1.14–3.12)
   TGC 0.093 0.57 (0.29–1.10) 0.145 0.58 (0.28–1.21)
   TCT (ref)
LC13 Dysphagia ERCC2 rs13181-rs3916874-rs238416 GCC 0.491 0.49 (0.06–3.73) 0.546 0.44 (0.03–6.32)
   TCC 0.062 2.10 (0.96–4.55) 0.048 2.82 (1.01–7.85)
   TGC 0.758 1.18 (0.42–3.33) 0.451 0.60 (0.16–2.28)
   TCT (ref)
SAS Anxiety state ERCC2 rs13181-rs3916874-rs238416 GCC 0.018 0.28 (0.10–0.80) 0.009 0.23 (0.08–0.69)
   TCC 0.401 1.20 (0.79–1.81) 0.479 1.18 (0.75–1.85)
   TGC 0.188 0.70 (0.41–1.19) 0.211 0.69 (0.39–1.23)
   TCT (ref)
  1. Covariates refer to environmental factors including:sex, age, occupation, marriage, education, number of children, smoking history, drinking history, medical insurance, pathological types, clinical stages, metastasis, concurrent symptoms, operation history, and chemotherapy
  2. When calculating the frequency, the molecule = the corresponding haplotype number, the denominator of the reference haplotype = 2 * (the sample number that contains the reference haplotype), the denominator of none reference haplotype = 2 * (the sample number that contains the reference and the current haplotypes). * means multiplication
  3. aβ and 95% confidence interval (CI) were reported (Linear regression was used for general health condition and functioning domains, anxiety and depression). bodds ratio (OR) and 95% CI were reported (Logistic regression was used for symptoms domains, anxiety and depression)