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Table 2 Univariate and multivariate analysis on factors associated with weight gain > 10% from diagnosis to T3 assessment, by stepwise logistic regression (n = 1171)

From: Weight and waist-to-hip ratio change pattern during the first five years of survival: data from a longitudinal observational Chinese breast cancer cohort

 

Univariate analysis

Multivariate analysis

OR

95%CI for OR

P

OR

95%CI for OR

P

Age group at diagnosis

  

0.001

  

0.022

 < 40

1

–

–

1

–

–

 40–49

0.848

0.474–1.516

0.578

1.000

0.518–1.925

0.996

 50–59

0.555

0.306–1.007

0.053

0.548

0.228–1.318

0.179

 ≥60

0.235

0.104–0.528

< 0.001

0.225

0.073–0.697

0.010

Education level

 High school or below

1

–

    

 College or above

1.314

0.817–2.115

0.260

   

Marital status

 Married or cohabitation

1

–

    

 Unmarried or divorced or widowed

1.169

0.783–1.748

0.445

   

Family income, HKD/month

 < 30,000

1

–

    

 ≥30,000

1.193

0.778–1.828

0.419

   

Employment status

 Working

1

–

 

1

–

 

 Not working

1.590

1.088–2.323

0.016

1.082

0.712–1.644

0.712

Number of comorbidities

  

0.026

  

0.160

 0

1

–

 

1

–

 

 1

0.932

0.609–1.428

0.747

1.071

0.680–1.687

0.768

 ≥2

0.312

0.134–0.727

0.007

0.442

0.181–1.076

0.072

Menopausal status from T0 to T3 assessment

  

0.033

  

0.158

 Pre-menopausal

1

–

 

1

–

 

 Peri-menopausal

0.688

0.421–1.124

0.135

0.865

0.492–1.522

0.616

 Post-menopausal

0.521

0.319–0.851

0.009

1.585

0.716–3.507

0.256

Parity

 0

1

–

 

1

–

 

 ≥1

0.586

0.393–0.873

0.009

0.771

0.499–1.919

0.242

AJCC stage

  

0.810

   

 0-I

1

–

    

 II

0.881

0.586–1.327

0.545

   

 III

0.993

0.583–1.691

0.980

   

ER status, %

      

 Positive

1

     

 Negative

1.305

0.870–1.959

0.198

   

PR status, %

 Positive

1

     

 Negative

1.042

0.716–1.515

0.831

   

HER 2 status, %

 Positive

1

     

 Negative

0.932

0.614–1.416

0.743

   

Type of surgery

 Mastectomy

1

–

    

 Conservation

0.898

0.612–1.319

0.584

   

 Chemotherapy, %

      

 No

1

–

    

 Yes

0.751

0.500–1.127

0.166

   

Radiotherapy, %

 No

1

     

 Yes

0.844

0.568–1.255

0.403

   

Endocrine therapy, %

 No

1

     

 Yes

0.852

0.562–1.290

0.448

   

Average sports participation

  

0.009

  

0.052

from T1 to T3 assessment

      

 Never

1

–

 

1

–

 

 Rarely/occasionally

0.886

0.516–1.519

0.659

0.884

0.506–1.545

0.664

 Frequently

0.458

0.247–0.849

0.013

0.523

0.271–0.998

0.049

Average dietary energy intake

      

from T1 to T3 assessment

      

 ≤median

1

–

    

 >median

1.057

0.729–1.532

0.769

   

Average dietary carbohydrate intake from T1 to T3

 assessment, g/1000 kcal/day

      

 ≤median

1

–

    

 >median

0.819

0.565–1.189

0.294

   

Average dietary fat intake from T1 to T3 assessment, g/1000

 kcal/day

      

 ≤median

1

–

    

 >median

1.266

0.872–1.837

0.216

   

Average vegetables and fruits intake from T1 to T3 assessment, g/day

 < 400

1

–

 

1

–

 

 ≥400

0.568

0.365–0.886

0.013

0.692

0.432–1.110

0.127

Average coffee intake from T1 to T3 assessment, ml/week

 < 200

1

–

    

 ≥200

1.067

0.703–1.620

0.760

   

Average sugar-sweetened beverage intake from T1 to T3 assessment, ml/week

 < 200

      

 ≥200

1.644

0.957–2.825

0.072

1.201

0.678–2.124

0.530

  1. Univariate logistic regression was performed to identify any potential factors associated with very substantial weight gain from diagnosis to T3 assessment. The potential variables with P < 0.1 in univariate analysis were included into the multivariate logistic regression model, including age group at diagnosis, employment status, number of comorbidities, menopausal status from T0 to T3 assessment, parity, average sports participation from T1 to T3 assessment and average sugar-sweetened beverage intake from T1 to T3 assessment
  2. From T0 to T3 assessment, patients’ menopause status could be classified as three groups: pre-menopausal, peri-menopausal and post-menopausal. Peri-menopausal was defined as pre-menopausal patients at T0 who described a change in menopause status at T3
  3. Abbreviations: OR odds ratio; CI confidence interval; HKD Hong Kong dollars; AJCC American joint Committee on cancer; ER estrogen receptor; PR progesterone receptor; HER 2 human epidermal-growth-factor receptor 2; MET metabolic equivalent of task; g gram
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BMC Cancer

ISSN: 1471-2407

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