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Table 2 Univariate and multivariate analysis on factors associated with weight gain > 10% from diagnosis to T3 assessment, by stepwise logistic regression (n = 1171)

From: Weight and waist-to-hip ratio change pattern during the first five years of survival: data from a longitudinal observational Chinese breast cancer cohort

  Univariate analysis Multivariate analysis
OR 95%CI for OR P OR 95%CI for OR P
Age group at diagnosis    0.001    0.022
 < 40 1 1
 40–49 0.848 0.474–1.516 0.578 1.000 0.518–1.925 0.996
 50–59 0.555 0.306–1.007 0.053 0.548 0.228–1.318 0.179
 ≥60 0.235 0.104–0.528 < 0.001 0.225 0.073–0.697 0.010
Education level
 High school or below 1     
 College or above 1.314 0.817–2.115 0.260    
Marital status
 Married or cohabitation 1     
 Unmarried or divorced or widowed 1.169 0.783–1.748 0.445    
Family income, HKD/month
 < 30,000 1     
 ≥30,000 1.193 0.778–1.828 0.419    
Employment status
 Working 1   1  
 Not working 1.590 1.088–2.323 0.016 1.082 0.712–1.644 0.712
Number of comorbidities    0.026    0.160
 0 1   1  
 1 0.932 0.609–1.428 0.747 1.071 0.680–1.687 0.768
 ≥2 0.312 0.134–0.727 0.007 0.442 0.181–1.076 0.072
Menopausal status from T0 to T3 assessment    0.033    0.158
 Pre-menopausal 1   1  
 Peri-menopausal 0.688 0.421–1.124 0.135 0.865 0.492–1.522 0.616
 Post-menopausal 0.521 0.319–0.851 0.009 1.585 0.716–3.507 0.256
Parity
 0 1   1  
 ≥1 0.586 0.393–0.873 0.009 0.771 0.499–1.919 0.242
AJCC stage    0.810    
 0-I 1     
 II 0.881 0.586–1.327 0.545    
 III 0.993 0.583–1.691 0.980    
ER status, %       
 Positive 1      
 Negative 1.305 0.870–1.959 0.198    
PR status, %
 Positive 1      
 Negative 1.042 0.716–1.515 0.831    
HER 2 status, %
 Positive 1      
 Negative 0.932 0.614–1.416 0.743    
Type of surgery
 Mastectomy 1     
 Conservation 0.898 0.612–1.319 0.584    
 Chemotherapy, %       
 No 1     
 Yes 0.751 0.500–1.127 0.166    
Radiotherapy, %
 No 1      
 Yes 0.844 0.568–1.255 0.403    
Endocrine therapy, %
 No 1      
 Yes 0.852 0.562–1.290 0.448    
Average sports participation    0.009    0.052
from T1 to T3 assessment       
 Never 1   1  
 Rarely/occasionally 0.886 0.516–1.519 0.659 0.884 0.506–1.545 0.664
 Frequently 0.458 0.247–0.849 0.013 0.523 0.271–0.998 0.049
Average dietary energy intake       
from T1 to T3 assessment       
 ≤median 1     
 >median 1.057 0.729–1.532 0.769    
Average dietary carbohydrate intake from T1 to T3
 assessment, g/1000 kcal/day       
 ≤median 1     
 >median 0.819 0.565–1.189 0.294    
Average dietary fat intake from T1 to T3 assessment, g/1000
 kcal/day       
 ≤median 1     
 >median 1.266 0.872–1.837 0.216    
Average vegetables and fruits intake from T1 to T3 assessment, g/day
 < 400 1   1  
 ≥400 0.568 0.365–0.886 0.013 0.692 0.432–1.110 0.127
Average coffee intake from T1 to T3 assessment, ml/week
 < 200 1     
 ≥200 1.067 0.703–1.620 0.760    
Average sugar-sweetened beverage intake from T1 to T3 assessment, ml/week
 < 200       
 ≥200 1.644 0.957–2.825 0.072 1.201 0.678–2.124 0.530
  1. Univariate logistic regression was performed to identify any potential factors associated with very substantial weight gain from diagnosis to T3 assessment. The potential variables with P < 0.1 in univariate analysis were included into the multivariate logistic regression model, including age group at diagnosis, employment status, number of comorbidities, menopausal status from T0 to T3 assessment, parity, average sports participation from T1 to T3 assessment and average sugar-sweetened beverage intake from T1 to T3 assessment
  2. From T0 to T3 assessment, patients’ menopause status could be classified as three groups: pre-menopausal, peri-menopausal and post-menopausal. Peri-menopausal was defined as pre-menopausal patients at T0 who described a change in menopause status at T3
  3. Abbreviations: OR odds ratio; CI confidence interval; HKD Hong Kong dollars; AJCC American joint Committee on cancer; ER estrogen receptor; PR progesterone receptor; HER 2 human epidermal-growth-factor receptor 2; MET metabolic equivalent of task; g gram