Table 1 Demographic characteristics of total patients and relationship between LC3 protein expression
Total patients, n (%) | LC3 expression | P-value | ||
|---|---|---|---|---|
Low (n = 7) | High (n = 33) | |||
Sex | ||||
Male | 32 (80.0) | 6 (100) | 26 (86.7) | 0.145 |
Female | 8 (20.0) | 1 (0) | 7 (13.3) | |
Age (years) | ||||
< 60 | 27 (67.5) | 5 (71.4) | 22 (66.7) | 0.807 |
≥ 60 | 13 (32.5) | 2 (28.6) | 11 (33.3) | |
Alcohol use | ||||
Absent | 28 (70.0) | 4 (57.1) | 24 (72.8) | 0.062 |
Present | 12 (30.0) | 3 (42.9) | 9 (27.2) | |
HBV positive | ||||
Negative | 24 (60) | 6 (85.7) | 18 (54.5) | 0.126 |
Positive | 16 (40.0) | 1 (14.3) | 15 (45.5) | |
HCV positive | ||||
Negative | 29 (72.5) | 6 (85.7) | 23 (69.7) | 0.389 |
Positive | 11 (27.5) | 1 (14.3) | 10 (30.3) | |
Cirrhosis | ||||
Absent | 27 (67.5) | 5 (71.5) | 22 (66.7) | 0.807 |
Present | 13 (32.5) | 2 (28.5) | 11 (33.3) | |
Edmondson-Steiner Grades | ||||
I-II | 29 (72.5) | 6 (85.7) | 20 (60.6) | 0.226 |
III | 11 (27.5) | 1 (14.3) | 13 (39.4) | |
Tumor size | ||||
< 5 cm | 13 (32.5) | 1 (14.3) | 12 (36.4) | 0.257 |
≥ 5 cm | 27 (67.5) | 6 (85.7) | 21 (63.6) | |
Tumor number | ||||
single | 37 (92.5) | 6 (85.7) | 31 (93.9) | 0.407 |
multiple | 3 (7.5) | 1 (14.3) | 2 (6.1) | |
AFP (ng/ml) | ||||
< 200 | 29 (72.5) | 4 (57.1) | 25 (75.8) | 0.316 |
≥ 200 | 11 (27.5) | 3 (42.9) | 8 (24.2) | |
Resection | ||||
R0 | 27 (67.5) | 5 (71.5) | 22 (66.7) | 0.807 |
R1/2 | 13 (32.5) | 2 (28.5) | 11 (33.3) | |
Microvascular invasion | ||||
Absent | 25 (62.5) | 3 (42.9) | 22 (66.7) | 0.237 |
Present | 15 (37.5) | 4 (57.1) | 11 (33.3) | |
Macrovascular invasion | ||||
Absent | 33 (82.5) | 1 (14.2) | 32 (96.9) | < 0.001 |
Present | 7 (17.5) | 6 (85.8) | 1 (3.1) | |
Lympho nodules metastasis | ||||
Absent | 33 (82.5) | 2 (28.5) | 31 (93.9) | < 0.001 |
Present | 7 (17.5) | 5 (71.5) | 2 (6.1) | |
AJCC stage | ||||
I-II | 33 (82.5) | 2 (28.5) | 31 (93.9) | < 0.001 |
III | 7 (17.5) | 5 (71.5) | 2 (6.1) | |
BCLC stage | ||||
A/B | 33 (82.5) | 3 (42.9) | 30 (90.9) | 0.006 |
C | 7 (17.5) | 4 (57.1) | 3 (9.1) | |
Recurrence | ||||
Absent | 30 (75.0%) | 2 (28.6) | 28 (84.8) | 0.001 |
Present | 10 (25.0%) | 5 (71.4) | 5 (15.2) | |
Mortality | ||||
Absent | 25 (62.5) | 1 (14.2) | 24 (72.8) | < 0.001 |
Present | 15 (37.5) | 6 (85.8) | 9 (27.2) | |