Skip to main content

Table 1 Demographic characteristics of total patients and relationship between LC3 protein expression

From: Role of autophagy-related protein in the prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgical resection

  Total patients, n (%) LC3 expression P-value
   Low (n = 7) High (n = 33)  
Sex
 Male 32 (80.0) 6 (100) 26 (86.7) 0.145
 Female 8 (20.0) 1 (0) 7 (13.3)  
Age (years)
  < 60 27 (67.5) 5 (71.4) 22 (66.7) 0.807
  ≥ 60 13 (32.5) 2 (28.6) 11 (33.3)  
Alcohol use
 Absent 28 (70.0) 4 (57.1) 24 (72.8) 0.062
 Present 12 (30.0) 3 (42.9) 9 (27.2)  
HBV positive
 Negative 24 (60) 6 (85.7) 18 (54.5) 0.126
 Positive 16 (40.0) 1 (14.3) 15 (45.5)  
HCV positive
 Negative 29 (72.5) 6 (85.7) 23 (69.7) 0.389
 Positive 11 (27.5) 1 (14.3) 10 (30.3)  
Cirrhosis
 Absent 27 (67.5) 5 (71.5) 22 (66.7) 0.807
 Present 13 (32.5) 2 (28.5) 11 (33.3)  
Edmondson-Steiner Grades
 I-II 29 (72.5) 6 (85.7) 20 (60.6) 0.226
 III 11 (27.5) 1 (14.3) 13 (39.4)  
Tumor size
  < 5 cm 13 (32.5) 1 (14.3) 12 (36.4) 0.257
  ≥ 5 cm 27 (67.5) 6 (85.7) 21 (63.6)  
Tumor number
 single 37 (92.5) 6 (85.7) 31 (93.9) 0.407
 multiple 3 (7.5) 1 (14.3) 2 (6.1)  
AFP (ng/ml)
  < 200 29 (72.5) 4 (57.1) 25 (75.8) 0.316
  ≥ 200 11 (27.5) 3 (42.9) 8 (24.2)  
Resection
 R0 27 (67.5) 5 (71.5) 22 (66.7) 0.807
 R1/2 13 (32.5) 2 (28.5) 11 (33.3)  
Microvascular invasion
 Absent 25 (62.5) 3 (42.9) 22 (66.7) 0.237
 Present 15 (37.5) 4 (57.1) 11 (33.3)  
Macrovascular invasion
 Absent 33 (82.5) 1 (14.2) 32 (96.9) < 0.001
 Present 7 (17.5) 6 (85.8) 1 (3.1)  
Lympho nodules metastasis
 Absent 33 (82.5) 2 (28.5) 31 (93.9) < 0.001
 Present 7 (17.5) 5 (71.5) 2 (6.1)  
AJCC stage
 I-II 33 (82.5) 2 (28.5) 31 (93.9) < 0.001
 III 7 (17.5) 5 (71.5) 2 (6.1)  
BCLC stage
 A/B 33 (82.5) 3 (42.9) 30 (90.9) 0.006
 C 7 (17.5) 4 (57.1) 3 (9.1)  
Recurrence
 Absent 30 (75.0%) 2 (28.6) 28 (84.8) 0.001
 Present 10 (25.0%) 5 (71.4) 5 (15.2)  
Mortality
 Absent 25 (62.5) 1 (14.2) 24 (72.8) < 0.001
 Present 15 (37.5) 6 (85.8) 9 (27.2)  
  1. Data are shown as number (percentage). HBV: Hepatitis B virus; HCV: Hepatitis C virus; INR: International normalize ratio; AFP: Alpha-fetoprotein; AJCC: American Joint Committee on Cancer; BCLC: Barcelona clinic liver cancer