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Table 5 Concentration of 177Lu (%IA/g) in tumor tissue in NET xenograft models at 1 h, 24 h 48 h and 168 h post injection of 177Lu-octreotate. The tumor-to-kidney (T/K) and tumor-to-blood (T/B) ratio is presented for 24 h post injection

From: Neuroblastoma xenograft models demonstrate the therapeutic potential of 177Lu-octreotate

Cell line Study Animal model(s) Inj. activity 177Lu activity concentration (%IA/g)
1 h 24 h 48 h 168 h T/K (24 h) T/B (24 h)
AR42Ja De Araújo et al. [43] nude mice 0.74 MBq 2.4 0.8 0.6 0.18 13
CA20948a Lewis et al. [44] rat 1.3 MBq 3.9 6.1 0.65 3.6 200
CA20948a de Jong et al. [45] rat 3 MBq 2.2 1.4 1100
GOT1 Dalmo et al. [35] nude mice 15 MBq 1.6 0.84 0.23 160
GOT2 Dalmo et al. [46] nude mice 5.0 MBq 0.37 0.094 0.073 23
GOT2 Dalmo et al. [46] nude mice 10 MBq 0.23 0.039 0.038 26
NCI-H69 Schmitt et al. [37] nude mice 3.3 MBq 3.7 1.2 1.7 470
CLB-BAR Present study nude mice 0.15 MBq 59 36 13 83 1.4
CLB-BAR Present study nude mice 1.5 MBq 49 25 4.6 270 1.2
CLB-BAR Present study nude mice 15 MBq 14 0.53 0.53 1.5 100 0.67
CLB-GE Present study nude mice 0.15 MBq 50 34 54 5 180 1.4
CLB-GE Present study nude mice 15 MBq 27 12 33 520 0.80
IMR-32 Present study nude mice 15 MBq 17 11 11 330 0.80
  1. a indicates rat origin and of exocrine type. The other cells or cell lines are human