Table 5 Concentration of ¹⁷⁷Lu (%IA/g) in tumor tissue in NET xenograft models at 1 h, 24 h 48 h and 168 h post injection of ¹⁷⁷Lu-octreotate. The tumor-to-kidney (T/K) and tumor-to-blood (T/B) ratio is presented for 24 h post injection

AR42J^a

De Araújo et al. [43]

nude mice

0.74 MBq

2.4

0.8

0.6

–

0.18

13

CA20948^a

Lewis et al. [44]

rat

1.3 MBq

3.9

6.1

–

0.65

3.6

200

CA20948^a

de Jong et al. [45]

rat

3 MBq

–

2.2

–

–

1.4

1100

GOT1

Dalmo et al. [35]

nude mice

15 MBq

–

1.6

–

0.84

0.23

160

GOT2

Dalmo et al. [46]

nude mice

5.0 MBq

–

0.37

–

0.094

0.073

23

GOT2

Dalmo et al. [46]

nude mice

10 MBq

–

0.23

–

0.039

0.038

26

NCI-H69

Schmitt et al. [37]

nude mice

3.3 MBq

–

3.7

–

1.2

1.7

470

CLB-BAR

Present study

nude mice

0.15 MBq

59

36

–

13

83

1.4

CLB-BAR

Present study

nude mice

1.5 MBq

49

25

–

4.6

270

1.2

CLB-BAR

Present study

nude mice

15 MBq

14

0.53

0.53

1.5

100

0.67

CLB-GE

Present study

nude mice

0.15 MBq

50

34

54

5

180

1.4

CLB-GE

Present study

nude mice

15 MBq

27

12

–

33

520

0.80

IMR-32

Present study

nude mice

15 MBq

17

11

–

11

330

0.80