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Table 3 Biodistribution of 177Lu-octreotate in IMR-32-bearing nude mice. Data is given as 177Lu activity concentration (%IA/g) in each tissue and tumor-to-normal-tissue 177Lu activity concentration ratios (T/N) at 1, 24 and 168 h after injection of 15 MBq 177Lu-octreotate (n = 5–6/group). Values are given as mean (SEM)

From: Neuroblastoma xenograft models demonstrate the therapeutic potential of 177Lu-octreotate

  177Lu activity concentration (%IA/g)
15 MBq
Time p.i. 1 h 24 h 168 h
 Adrenals 3.2 (0.3) 1.1 (0.2) 0.61 (0.14)
 Blood 2.3 (0.3) 0.039 (0.006) 0.0087 (0.0013)
 Brain 0.22 (0.02) 0.046 (0.003) 0.017 (0.001)
 Kidneys 43 (3) 18 (1) 1.4 (0.1)
 Liver 2.9 (0.4) 0.34 (0.04) 0.18 (0.03)
 Lungs 6.3 (1.1) 1.3 (0.1) 0.39 (0.03)
 Spleen 3.6 (0.4) 0.30 (0.02) 0.19 (0.04)
 Tumor 17 (2) 11 (1) 11 (3)
Tumor-to-normal-tissue concentration ratio (T/N)
T/N 1 h 24 h 168 h
 Adrenals 6.1 (0.9) 14 (3) 22 (6)
 Blood 8.8 (1.1) 330 (46) 1300 (290)
 Brain 86 (12) 330 (84) 740 (190)
 Kidneys 0.38 (0.04) 0.80 (0.16) 7.8 (1.9)
 Liver 6.9 (0.9) 41 (7) 70 (22)
 Lungs 3.0 (0.3) 11 (2) 29 (8)
 Spleen 5.4 (0.6) 50 (12) 100 (47)