Table 2 Biodistribution of ¹⁷⁷Lu-octreotate in CLB-GE-bearing nude mice. Data is given as ¹⁷⁷Lu activity concentration (%IA/g) in each tissue and tumor-to-normal-tissue ¹⁷⁷Lu activity concentration ratios (T/N) at 1, 24, 48 (only for 15 MBq) and 168 h p.i. with 0.15 or 15 MBq ¹⁷⁷Lu-octreotate (n = 5–6/group). Values are given as mean (SEM)

Time p.i.

1 h

24 h

48 h

168 h

1 h

24 h

168 h

 Adrenals

27 (7)

14 (2)

13 (2)

5.2 (0.7)

5.5 (1.2)

1.5 (0.1)

0.63 (0.11)

 Blood

3.1 (1.0)

0.35 (0.11)

0.16 (0.02)

0.11 (0.04)

1.5 (0.6)

0.044 (0.005)

0.014 (0.002)

 Brain

0.33 (0.05)

0.19 (0.07)

0.17 (0.06)

0.045 (0.002)

0.33 (0.10)

0.084 (0.020)

0.019 (0.002)

 Kidneys

59 (7)

25 (2)

12 (2)

1.6 (0.2)

37 (2)

15 (1)

1.2 (0.2)

 Liver

5.7 (0.6)

1.2 (0.1)

1.2 (0.1)

0.60 (0.06)

1.3 (0.1)

0.42 (0.04)

0.11 (0.01)

 Lungs

90 (15)

35 (3)

27 (4)

8.7 (1.0)

6.4 (0.8)

1.4 (0.1)

0.49 (0.03)

 Spleen

8.5 (1.2)

2.8 (0.1)

2.9 (0.4)

1.2 (0.1)

1.3 (0.2)

0.31 (0.02)

0.16 (0.01)

 Tumor

50 (14)

34 (3)

54 (19)

5.0 (1.1)

27 (7)

12 (1)

33 (8)

T/N

1 h

24 h

48 h

168 h

1 h

24 h

168 h

 Adrenals

6.7 (4.7)

2.7 (0.3)

3.8 (0.7)

0.96 (0.15)

4.7 (0.2)

8.2 (0.7)

34 (11)

 Blood

25 (11)

180 (71)

320 (62)

72 (23)

21 (3)

520 (160)

2800 (970)

 Brain

200 (70)

270 (66)

400 (130)

110 (24)

89 (12)

170 (28)

1800 (470)

 Kidneys

0.93 (0.24)

1.4 (0.1)

4.6 (1.1)

3.1 (0.4)

0.69 (0.13)

0.80 (0.06)

24 (8)

 Liver

9.3 (2.2)

28 (3)

45 (13)

8.0 (1.0)

20 (4)

29 (2)

220 (73)

 Lungs

0.62 (0.16)

0.99 (0.10)

2.1 (0.5)

0.57 (0.08)

4.0 (0.5)

8.5 (0.3)

66 (15)

 Spleen

6.8 (1.8)

12 (1.4)

20 (5.8)

4.2 (0.6)

20 (2)

39 (2)

150 (56)