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Table 2 Biodistribution of 177Lu-octreotate in CLB-GE-bearing nude mice. Data is given as 177Lu activity concentration (%IA/g) in each tissue and tumor-to-normal-tissue 177Lu activity concentration ratios (T/N) at 1, 24, 48 (only for 15 MBq) and 168 h p.i. with 0.15 or 15 MBq 177Lu-octreotate (n = 5–6/group). Values are given as mean (SEM)

From: Neuroblastoma xenograft models demonstrate the therapeutic potential of 177Lu-octreotate

  177Lu activity concentration (%IA/g)
0.15 MBq 15 MBq
Time p.i. 1 h 24 h 48 h 168 h 1 h 24 h 168 h
 Adrenals 27 (7) 14 (2) 13 (2) 5.2 (0.7) 5.5 (1.2) 1.5 (0.1) 0.63 (0.11)
 Blood 3.1 (1.0) 0.35 (0.11) 0.16 (0.02) 0.11 (0.04) 1.5 (0.6) 0.044 (0.005) 0.014 (0.002)
 Brain 0.33 (0.05) 0.19 (0.07) 0.17 (0.06) 0.045 (0.002) 0.33 (0.10) 0.084 (0.020) 0.019 (0.002)
 Kidneys 59 (7) 25 (2) 12 (2) 1.6 (0.2) 37 (2) 15 (1) 1.2 (0.2)
 Liver 5.7 (0.6) 1.2 (0.1) 1.2 (0.1) 0.60 (0.06) 1.3 (0.1) 0.42 (0.04) 0.11 (0.01)
 Lungs 90 (15) 35 (3) 27 (4) 8.7 (1.0) 6.4 (0.8) 1.4 (0.1) 0.49 (0.03)
 Spleen 8.5 (1.2) 2.8 (0.1) 2.9 (0.4) 1.2 (0.1) 1.3 (0.2) 0.31 (0.02) 0.16 (0.01)
 Tumor 50 (14) 34 (3) 54 (19) 5.0 (1.1) 27 (7) 12 (1) 33 (8)
Tumor-to-normal-tissue concentration ratio (T/N)
T/N 1 h 24 h 48 h 168 h 1 h 24 h 168 h
 Adrenals 6.7 (4.7) 2.7 (0.3) 3.8 (0.7) 0.96 (0.15) 4.7 (0.2) 8.2 (0.7) 34 (11)
 Blood 25 (11) 180 (71) 320 (62) 72 (23) 21 (3) 520 (160) 2800 (970)
 Brain 200 (70) 270 (66) 400 (130) 110 (24) 89 (12) 170 (28) 1800 (470)
 Kidneys 0.93 (0.24) 1.4 (0.1) 4.6 (1.1) 3.1 (0.4) 0.69 (0.13) 0.80 (0.06) 24 (8)
 Liver 9.3 (2.2) 28 (3) 45 (13) 8.0 (1.0) 20 (4) 29 (2) 220 (73)
 Lungs 0.62 (0.16) 0.99 (0.10) 2.1 (0.5) 0.57 (0.08) 4.0 (0.5) 8.5 (0.3) 66 (15)
 Spleen 6.8 (1.8) 12 (1.4) 20 (5.8) 4.2 (0.6) 20 (2) 39 (2) 150 (56)