From: Neuroblastoma xenograft models demonstrate the therapeutic potential of 177Lu-octreotate
 | 177Lu activity concentration (%IA/g) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
0.15 MBq | 1.5 MBq | 15 MBq | ||||||||
Time p.i. | 1 h | 24 h | 168 h | 1 h | 24 h | 168 h | 1 h | 24 h | 48 h | 168 h |
 Adrenals | 17 (2) | 16 (4) | 3.3 (0.7) | 6.6 (1.6) | 3.4 (0.5) | 1.0 (0.2) | 1.8 (0.1) | 0.16 (0.05) | 0.077 (0.005) | 0.26 (0.07) |
 Blood | 2.0 (0.1) | 0.51 (0.1) | 0.18 (0.05) | 1.5 (0.13 | 0.13 (0.04) | 0.095 (0.05) | 0.78 (0.11) | 0.0053 (0.0015) | 0.0029 (0.0005) | 0.009 (0.002) |
 Brain | 0.35 (0.08) | 0.29 (0.08) | 0.058 (0.012) | 0.28 (0.10) | 0.074 (0.01) | 0.027 (0.006) | 0.22 (0.05) | 0.0078 (0.0008) | 0.0074 (0.0006) | 0.014 (0.002) |
 Kidneys | 58 (6) | 25 (2) | 3.9 (0.5) | 61 (3) | 22 (1) | 2.8 (0.2) | 57 (6) | 2.0 (0.7) | 1.6 (0.2) | 1.2 (0.1) |
 Liver | 4.2 (0.2) | 1.3 (0.1) | 0.73 (0.07) | 2.0 (0.4) | 0.52 (0.03) | 0.22 (0.02) | 1.4 (0.2) | 0.028 (0.008) | 0.026 (0.002) | 0.068 (0.003) |
 Lungs | 54 (2) | 17 (2) | 4.1 (0.5) | 16 (2) | 4.1 (0.9) | 1.1 (0.1) | 3.8 (0.4) | 0.14 (0.03) | 0.11 (0.00) | 0.14 (0.01) |
 Spleen | 5.7 (0.5) | 1.5 (0.3) | 1.5 (0.3) | 5.1 (2.1) | 1.1 (0.1) | 0.65 (0.04) | 1.1 (0.2) | 0.052 (0.010) | 0.054 (0.002) | 0.13 (0.01) |
 Tumor | 59 (9) | 36 (3) | 13 (3) | 49 (8) | 25 (1) | 4.6 (0.6) | 14 (1) | 0.53 (0.16) | 0.53 (0.03) | 1.5 (0.3) |
Tumor-to-normal-tissue concentration ratio (T/N) | ||||||||||
T/N | 1 h | 24 h | 168 h | 1 h | 24 h | 168 h | 1 h | 24 h | 48 h | 168 h |
 Adrenals | 3.6 (0.6) | 2.7 (1.1) | 4.7 (1.4) | 9.0 (2.0) | 7.8 (0.7) | 6.4 (1.9) | 7.7 (0.7) | 3.3 (0.2) | 7.1 (0.6) | 5.1 (1.5) |
 Blood | 30 (3) | 83 (17) | 96 (27) | 34 (6.0) | 270 (64) | 88 (29) | 19 (2) | 101 (16) | 200 (24) | 140 (37) |
 Brain | 200 (42) | 160 (30) | 310 (96) | 240 (60) | 360 (38) | 200 (40) | 71 (14) | 65 (15) | 73 (6) | 73 (13) |
 Kidneys | 1.1 (0.2) | 1.4 (0.1) | 3.3 (0.6) | 0.81 (0.11) | 1.2 (0.1) | 1.6 (0.1) | 0.25 (0.01) | 0.67 (0.37) | 0.34 (0.03) | 0.97 (0.23) |
 Liver | 14 (2) | 27 (1) | 18 (3) | 28 (5) | 50 (3) | 21 (3) | 10 (1) | 22 (4) | 21 (1) | 15 (3) |
 Lungs | 1.1 (0.2) | 2.2 (0.1) | 3.4 (0.7) | 3.0 (0.4) | 13 (7) | 4.2 (0.6) | 3.7 (0.4) | 3.7 (0.8) | 4.7 (0.2) | 6.4 (2.3) |
 Spleen | 10 (1.0) | 27 (3.9) | 12 (4) | 14 (3) | 25 (3) | 7.3 (1.1) | 14 (2) | 9.5 (1.6) | 9.9 (0.5) | 9.5 (3.0) |