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Table 1 Biodistribution of 177Lu-octreotate in CLB-BAR-bearing nude mice. Data is given as 177Lu activity concentration (%IA/g) in each tissue and tumor-to-normal-tissue 177Lu activity concentration ratios (T/N) at 1, 24, 48 (only for 15 MBq) and 168 h post injection of 0.15, 1.5 or 15 MBq 177Lu-octreotate (n = 5–6/group). Values are given as mean (SEM)

From: Neuroblastoma xenograft models demonstrate the therapeutic potential of 177Lu-octreotate

  177Lu activity concentration (%IA/g)
0.15 MBq 1.5 MBq 15 MBq
Time p.i. 1 h 24 h 168 h 1 h 24 h 168 h 1 h 24 h 48 h 168 h
 Adrenals 17 (2) 16 (4) 3.3 (0.7) 6.6 (1.6) 3.4 (0.5) 1.0 (0.2) 1.8 (0.1) 0.16 (0.05) 0.077 (0.005) 0.26 (0.07)
 Blood 2.0 (0.1) 0.51 (0.1) 0.18 (0.05) 1.5 (0.13 0.13 (0.04) 0.095 (0.05) 0.78 (0.11) 0.0053 (0.0015) 0.0029 (0.0005) 0.009 (0.002)
 Brain 0.35 (0.08) 0.29 (0.08) 0.058 (0.012) 0.28 (0.10) 0.074 (0.01) 0.027 (0.006) 0.22 (0.05) 0.0078 (0.0008) 0.0074 (0.0006) 0.014 (0.002)
 Kidneys 58 (6) 25 (2) 3.9 (0.5) 61 (3) 22 (1) 2.8 (0.2) 57 (6) 2.0 (0.7) 1.6 (0.2) 1.2 (0.1)
 Liver 4.2 (0.2) 1.3 (0.1) 0.73 (0.07) 2.0 (0.4) 0.52 (0.03) 0.22 (0.02) 1.4 (0.2) 0.028 (0.008) 0.026 (0.002) 0.068 (0.003)
 Lungs 54 (2) 17 (2) 4.1 (0.5) 16 (2) 4.1 (0.9) 1.1 (0.1) 3.8 (0.4) 0.14 (0.03) 0.11 (0.00) 0.14 (0.01)
 Spleen 5.7 (0.5) 1.5 (0.3) 1.5 (0.3) 5.1 (2.1) 1.1 (0.1) 0.65 (0.04) 1.1 (0.2) 0.052 (0.010) 0.054 (0.002) 0.13 (0.01)
 Tumor 59 (9) 36 (3) 13 (3) 49 (8) 25 (1) 4.6 (0.6) 14 (1) 0.53 (0.16) 0.53 (0.03) 1.5 (0.3)
Tumor-to-normal-tissue concentration ratio (T/N)
T/N 1 h 24 h 168 h 1 h 24 h 168 h 1 h 24 h 48 h 168 h
 Adrenals 3.6 (0.6) 2.7 (1.1) 4.7 (1.4) 9.0 (2.0) 7.8 (0.7) 6.4 (1.9) 7.7 (0.7) 3.3 (0.2) 7.1 (0.6) 5.1 (1.5)
 Blood 30 (3) 83 (17) 96 (27) 34 (6.0) 270 (64) 88 (29) 19 (2) 101 (16) 200 (24) 140 (37)
 Brain 200 (42) 160 (30) 310 (96) 240 (60) 360 (38) 200 (40) 71 (14) 65 (15) 73 (6) 73 (13)
 Kidneys 1.1 (0.2) 1.4 (0.1) 3.3 (0.6) 0.81 (0.11) 1.2 (0.1) 1.6 (0.1) 0.25 (0.01) 0.67 (0.37) 0.34 (0.03) 0.97 (0.23)
 Liver 14 (2) 27 (1) 18 (3) 28 (5) 50 (3) 21 (3) 10 (1) 22 (4) 21 (1) 15 (3)
 Lungs 1.1 (0.2) 2.2 (0.1) 3.4 (0.7) 3.0 (0.4) 13 (7) 4.2 (0.6) 3.7 (0.4) 3.7 (0.8) 4.7 (0.2) 6.4 (2.3)
 Spleen 10 (1.0) 27 (3.9) 12 (4) 14 (3) 25 (3) 7.3 (1.1) 14 (2) 9.5 (1.6) 9.9 (0.5) 9.5 (3.0)