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Table 1 Biodistribution of 177Lu-octreotate in CLB-BAR-bearing nude mice. Data is given as 177Lu activity concentration (%IA/g) in each tissue and tumor-to-normal-tissue 177Lu activity concentration ratios (T/N) at 1, 24, 48 (only for 15 MBq) and 168 h post injection of 0.15, 1.5 or 15 MBq 177Lu-octreotate (n = 5–6/group). Values are given as mean (SEM)

From: Neuroblastoma xenograft models demonstrate the therapeutic potential of 177Lu-octreotate

 

177Lu activity concentration (%IA/g)

0.15 MBq

1.5 MBq

15 MBq

Time p.i.

1 h

24 h

168 h

1 h

24 h

168 h

1 h

24 h

48 h

168 h

 Adrenals

17 (2)

16 (4)

3.3 (0.7)

6.6 (1.6)

3.4 (0.5)

1.0 (0.2)

1.8 (0.1)

0.16 (0.05)

0.077 (0.005)

0.26 (0.07)

 Blood

2.0 (0.1)

0.51 (0.1)

0.18 (0.05)

1.5 (0.13

0.13 (0.04)

0.095 (0.05)

0.78 (0.11)

0.0053 (0.0015)

0.0029 (0.0005)

0.009 (0.002)

 Brain

0.35 (0.08)

0.29 (0.08)

0.058 (0.012)

0.28 (0.10)

0.074 (0.01)

0.027 (0.006)

0.22 (0.05)

0.0078 (0.0008)

0.0074 (0.0006)

0.014 (0.002)

 Kidneys

58 (6)

25 (2)

3.9 (0.5)

61 (3)

22 (1)

2.8 (0.2)

57 (6)

2.0 (0.7)

1.6 (0.2)

1.2 (0.1)

 Liver

4.2 (0.2)

1.3 (0.1)

0.73 (0.07)

2.0 (0.4)

0.52 (0.03)

0.22 (0.02)

1.4 (0.2)

0.028 (0.008)

0.026 (0.002)

0.068 (0.003)

 Lungs

54 (2)

17 (2)

4.1 (0.5)

16 (2)

4.1 (0.9)

1.1 (0.1)

3.8 (0.4)

0.14 (0.03)

0.11 (0.00)

0.14 (0.01)

 Spleen

5.7 (0.5)

1.5 (0.3)

1.5 (0.3)

5.1 (2.1)

1.1 (0.1)

0.65 (0.04)

1.1 (0.2)

0.052 (0.010)

0.054 (0.002)

0.13 (0.01)

 Tumor

59 (9)

36 (3)

13 (3)

49 (8)

25 (1)

4.6 (0.6)

14 (1)

0.53 (0.16)

0.53 (0.03)

1.5 (0.3)

Tumor-to-normal-tissue concentration ratio (T/N)

T/N

1 h

24 h

168 h

1 h

24 h

168 h

1 h

24 h

48 h

168 h

 Adrenals

3.6 (0.6)

2.7 (1.1)

4.7 (1.4)

9.0 (2.0)

7.8 (0.7)

6.4 (1.9)

7.7 (0.7)

3.3 (0.2)

7.1 (0.6)

5.1 (1.5)

 Blood

30 (3)

83 (17)

96 (27)

34 (6.0)

270 (64)

88 (29)

19 (2)

101 (16)

200 (24)

140 (37)

 Brain

200 (42)

160 (30)

310 (96)

240 (60)

360 (38)

200 (40)

71 (14)

65 (15)

73 (6)

73 (13)

 Kidneys

1.1 (0.2)

1.4 (0.1)

3.3 (0.6)

0.81 (0.11)

1.2 (0.1)

1.6 (0.1)

0.25 (0.01)

0.67 (0.37)

0.34 (0.03)

0.97 (0.23)

 Liver

14 (2)

27 (1)

18 (3)

28 (5)

50 (3)

21 (3)

10 (1)

22 (4)

21 (1)

15 (3)

 Lungs

1.1 (0.2)

2.2 (0.1)

3.4 (0.7)

3.0 (0.4)

13 (7)

4.2 (0.6)

3.7 (0.4)

3.7 (0.8)

4.7 (0.2)

6.4 (2.3)

 Spleen

10 (1.0)

27 (3.9)

12 (4)

14 (3)

25 (3)

7.3 (1.1)

14 (2)

9.5 (1.6)

9.9 (0.5)

9.5 (3.0)