Table 1 Multivariate Cox analysis of prognostic AS signatures of each AS type

PKMYT1

33,330

AA

−4.62365

0.009817

0.000149

0.644696

0.030344

POLR2H

67,943

AA

12.70464

329,270.6

42.50452

2.55E+ 09

0.005425

EPN1

52,138

AA

−8.32915

0.000241

2.21E-08

2.630785

0.079083

MEIS3

50,645

AA

2.326581

10.24286

2.092053

50.1499

0.004095

SEC16A

88,181

AA

6.467639

643.9617

2.325998

178,283.4

0.024185

XRCC4

72,698

AA

−1.38736

0.249733

0.081034

0.769636

0.015695

LTC4S

74,924

AA

−43.1454

1.83E-19

1.65E-30

2.02E-08

0.000883

MSS51

12,150

AA

−17.2217

3.32E-08

2.55E-14

0.043206

0.016516

SHC1

7856

AA

−8.01876

0.000329

2.09E-08

5.189885

0.10394

PTPN7

9405

AA

−13.4042

1.51E-06

2.87E-09

0.000792

2.74E-05

MLST8

33,226

AA

−12.8429

2.64E-06

1.63E-11

0.42889

0.035881

RPL13

392,312

AD

9.429979

12,456.27

155.7049

996,491.4

2.47E-05

COPB1

14,469

AD

3.238635

25.49888

0.891659

729.1948

0.058366

TATDN1

85,085

AD

5.362926

213.3483

1.339859

33,971.85

0.038167

CPNE1

59,205

AD

−4.09642

0.016632

0.000334

0.827904

0.039909

GCFC2

54,161

AD

−10.1517

3.90E-05

5.93E-09

0.256718

0.02363

GEMIN6

53,288

AD

−10.9105

1.83E-05

8.47E-09

0.039375

0.005338

ATXN2L

35,857

AD

2.993779

19.96097

1.791751

222.3748

0.014927

RPS15A

34,266

AD

11.40439

89,714.7

0.932723

8.63E+ 09

0.051407

STARD10

17,646

AD

−24.3236

2.73E-11

2.27E-18

0.000329

0.003453

ECHDC2

90,971

ES

−1.24895

0.286807

0.05954

1.381561

0.119465

ERCC1

50,443

ES

−7.79417

0.000412

3.53E-07

0.480997

0.030535

COPZ2

120,285

ES

3.396763

29.86727

1.78974

498.4265

0.018017

RBCK1

58,453

ES

−17.8953

1.69E-08

7.55E-14

0.003788

0.004413

NDUFA12

23,740

ES

−3.30745

0.036609

0.000847

1.582308

0.085221

KANSL3

54,543

ES

−7.00065

0.000911

2.05E-05

0.04055

0.0003

CASP10

56,809

ES

−2.28213

0.102067

0.0061

1.707783

0.112368

TBC1D7

75,381

ES

−5.37593

0.004627

0.000122

0.175366

0.003748

ACOXL

54,941

AT

−2.76667

0.062871

0.013075

0.302304

0.000554

ESCO2

83,184

AT

−2.59645

0.074538

0.005148

1.079276

0.056908

ARL5A

55,593

AT

−31.2748

2.62E-14

3.68E-20

1.86E-08

5.37E-06

EPS15L1

48,158

AT

−5.22216

0.005396

0.000119

0.243627

0.007223

SRPK2

81,281

AT

−12.2981

4.56E-06

6.00E-11

0.346551

0.031971

C5orf38

71,503

AT

−3.80851

0.022181

0.003116

0.157876

0.000143

SLC35G1

12,567

AT

−2.08066

0.124848

0.009697

1.607419

0.110508

GOLGA6L4

32,284

RI

−6.81726

0.001095

1.56E-06

0.769218

0.041508

AKIP1

14,280

RI

2.88328

17.87281

1.894855

168.5813

0.011797

TRAPPC2

88,516

RI

3.320201

27.66591

1.281781

597.1397

0.034145

MBD3

46,525

RI

14.74354

2,529,512

305.7635

2.09E+ 10

0.001358

TMEM33

69,137

RI

−6.68218

0.001253

6.35E-07

2.471107

0.084302

EEF1B2

57,143

RI

−6.42918

0.001614

1.51E-06

1.729919

0.070917

CERS5

99,714

ME

1.045024

2.843466

1.051878

7.686538

0.039432

SMPD4

55,291

ME

2.387929

10.89091

0.826019

143.5948

0.069569

THNSL2

54,469

ME

−2.99269

0.050153

0.004231

0.594429

0.017678

ZNF140

204,379

ME

−5.46035

0.004252

4.34E-05

0.416614

0.019581

RNF121

17,448

ME

−1.70312

0.182114

0.050196

0.660716

0.00959

TTC13

10,258

ME

2.143182

8.526528

1.524471

47.68977

0.014687

ZFP64

59,809

AP

−1.49769

0.223647

0.040284

1.241632

0.086805

YY1AP1

8098

AP

−3.10861

0.044663

0.001998

0.998353

0.049879

DHPS

47,825

AP

−23.3753

7.05E-11

1.88E-19

0.026407

0.020299

LIMA1

21,691

AP

−2.42334

0.088625

0.008378

0.937537

0.044056

MORF4L2

89,765

AP

−3.76226

0.023231

0.000582

0.927201

0.045484