Skip to main content

Table 4 Threshold effect analysis of DI on adverse clinical outcomes using piece-wise linear regression

From: DNA index as prognostic factor in childhood acute lymphoblastic leukemia in the COG-TARGET database

DI

Crude

aAdjust

LogRR(95%CI)

P value

LogRR(95%CI)

P value

< 1.1

0.6 (0.1, 2.9)

0.559

0.7 (0.1, 3.2)

0.597

≥1.1, < 1.2

0.0 (0.0, 1.7)

0.077

0.0 (0.0, 0.8)

0.041

≥1.2

2.8 (0.5, 15.3)

0.236

8.8 (1.4, 56.0)

0.021

  1. Crude:none adjustment
  2. aAdjusted: gender; age; race; chemotherapy protocol; WBC; CNS Status; fusion gene; prednisone response; BM blasts on Day+ 29; immunophenotype; karyotype