Table 3 Multivariate analysis for EFS and OS among pediatric patients with ALL
From: DNA index as prognostic factor in childhood acute lymphoblastic leukemia in the COG-TARGET database
Outcome | Variable | HR (95% CI) | P value |
|---|---|---|---|
EFS | Age ≥ 10 | 0.9 (0.6, 1.5) | 0.771 |
Female | 0.9 (0.7, 1.0) | 0.087 | |
Non-white | 1.0 (0.8, 1.2) | 0.848 | |
WBC ≥ 50 | 1.3 (0.9, 1.7) | 0.110 | |
B Cell ALL | 0.2 (0.1, 0.2) | < 0.001 | |
DI | 0.9 (0.3, 2.0) | 0.048 | |
Hyperdiploid | 0.8 (0.6, 1.0) | 0.110 | |
ETV6/RUNX1 | 0.6 (0.4, 0.8) | 0.003 | |
BCR/ABL1 | 1.6 (1.0, 2.5) | 0.048 | |
PPR | 1.3 (1.1, 1.6) | 0.004 | |
BM NR on Day+ 29 | 3.1 (2.1, 4.5) | < 0.001 | |
AALL0434 protocol | 0.3 (0.1, 1.2) | 0.07 | |
OS | Age ≥ 10 | 1.3 (0.7, 2.3) | 0.457 |
Female | 0.9 (0.7, 1.1) | 0.208 | |
Non-white | 1.0 (0.8, 1.4) | 0.727 | |
WBC ≥ 50 | 1.5 (1.0, 2.1) | 0.026 | |
B Cell ALL | 0.2 (0.1, 1.3) | 0.054 | |
DI | 0.1 (0.0, 0.5) | 0.001 | |
Hyperdiploid | 0.6 (0.5, 0.9) | 0.015 | |
ETV6/RUNX1 | 0.3 (0.2, 0.5) | < 0.001 | |
BCR/ABL1 | 1.3 (0.7, 2.3) | 0.367 | |
PPR | 1.3 (1.0, 1.6) | 0.055 | |
BM NR on Day+ 29 | 1.7 (1.1, 2.8) | 0.026 | |
AALL0434 protocol | 0.4 (0.2, 1.6) | 0.125 |