From: DNA index as prognostic factor in childhood acute lymphoblastic leukemia in the COG-TARGET database
Characteristics | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
OR(95%CI) | P value | OR(95%CI) | P value | |
Age(y) | 1.1 (1.0, 1.2) | 0.004 | 0.9 (0.8, 1.0) | 0.127 |
Age group | ||||
≥ 1, < 10 | Ref | < 0.001 | Ref | 0.014 |
≥ 10 | 3.2 (1.6, 6.1) | 9.7 (1.6, 59.1) | ||
Gender | ||||
Male | Ref | 0.615 | Ref | 0.330 |
Female | 1.2 (0.6, 2.2) | 1.4 (0.7, 3.0) | ||
Race | ||||
White | Ref | Ref | ||
Non-white | 1.6 (0.8, 3.0) | 0.146 | 1.6 (0.8, 3.3) | 0.229 |
WBC | 1.0 (1.0, 1.0) | < 0.001 | 1.0 (1.0, 1.0) | 0.466 |
WBC group | ||||
< 50 | Ref | < 0.001 | Ref | 0.069 |
≥ 50 | 3.2 (1.7, 6.2) | 2.5 (0.9, 6.8) | ||
Immunophenotype | ||||
B-Precursor | Ref | Ref | ||
B Cell ALL | 0.2 (0.1, 0.6) | 0.003 | 0.2 (0.0, 0.7) | 0.019 |
T Cell ALL | 0.2 (0.0, 0.9) | 0.032 | 1.0 | |
B precursor (Non-T, Non-B) | 1.1 (0.5, 2.4) | 0.773 | 0.1 (0.0, 0.8) | 0.034 |
DI | 0.2 (0.0, 3.1) | 0.249 | 2.0 (0.0, 336.1) | 0.790 |
Karyotype | ||||
Normal | Ref | Ref | ||
hypodiploidy | 0.9 (0.3, 2.9) | 0.816 | 0.5 (0.1, 2.5) | 0.384 |
hyperdiploid | 0.2 (0.1, 0.7) | 0.011 | 0.2 (0.0, 0.6) | 0.009 |
NA | 0.7 (0.3, 1.5) | 0.347 | 0.7 (0.3, 1.6) | 0.393 |
Fusion gene | ||||
Negative | Ref | Ref | ||
ETV6/RUNX1 | 0.0 (0.0, Inf) | 0.983 | 0.0 (0.0, Inf) | 0.988 |
MLL | 2.3 (0.7, 7.8) | 0.194 | 1.4 (0.3, 5.8) | 0.683 |
TCF3/PBX1 | 0.4 (0.1, 3.3) | 0.426 | 0.9 (0.1, 7.1) | 0.882 |
BCR/ABL1 | 12.9 (5.7, 29.7) | < 0.001 | 7.6 (2.4, 24.3) | < 0.001 |
Unknown | 0.8 (0.3, 1.9) | 0.598 | 1.0 (0.3, 2.8) | 0.935 |
CNS status | ||||
CNS1 | Ref | Ref | ||
CNS2 | 1.4 (0.6, 3.1) | 0.409 | 0.8 (0.3, 2.1) | 0.624 |
CNS3 | 1.8 (0.6, 6.2) | 0.319 | 1.0 (0.2, 4.7) | 0.960 |
Prednisone response | ||||
Good | Ref | < 0.001 | Ref | < 0.001 |
Poor | 18.3 (7.2, 46.9) | 16.9 (6.3, 45.9) | ||
Chemotherapy protocol | ||||
9906 | Ref | Ref | ||
AALL0232 | 0.7 (0.3, 1.4) | 0.291 | 0.0 (0.0, 0.5) | 0.011 |
AALL0331 | 0.1 (0.0, 0.5) | 0.003 | 0.2 (0.0, 3.0) | 0.241 |
AALL0434 | 0.2 (0.0, 0.7) | 0.018 | 0.0 (0.0, 0.1) | < 0.001 |