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Table 3 Subgroup analyses for overall survival

From: Clinical significance of FBXW7 tumor suppressor gene mutations and expression in human colorectal cancer: a systemic review and meta-analysis

Outcome Characteristics Number of studies HR(95%CI) I2 (%) Ph Z P value
Recruitment time Before 2009 5 1.24 (0.93–1.65) 88 <  0.01 1.46 0.14
After 2009 5 1.32 (1.17–1.50) 32 0.21 4.43 <  0.01
Region Eastern asia 8 1.27 (1.04–1.55) 77 <  0.01 2.31 0.02
Other regions 2 1.18 (0.87–1.61) 62 0.10 1.08 0.28
FBXW7 detection method IHC/qRT-PCR 6 1.39 (1.22–1.59) 46 0.10 4.95 <  0.01
Sequencing 4 1.17 (0.94–1.47) 73 0.01 1.40 0.16
Sample Size ≥ 100 7 1.23 (1.01–1.51) 81 <  0.01 2.06 0.04
<  100 3 1.33 (1.09–1.63) 0 0.85 2.81 <  0.01
Data types Univariate 7 1.13 (0.94–1.35) 56 0.03 1.28 0.20
Multivariate 3 1.47 (1.25–1.74) 50 0.13 4.56 <  0.01