Outcome | Characteristics | Number of studies | HR(95%CI) | I2 (%) | Ph | Z | P value |
---|---|---|---|---|---|---|---|
Recruitment time | Before 2009 | 5 | 1.24 (0.93–1.65) | 88 | <  0.01 | 1.46 | 0.14 |
After 2009 | 5 | 1.32 (1.17–1.50) | 32 | 0.21 | 4.43 | <  0.01 | |
Region | Eastern asia | 8 | 1.27 (1.04–1.55) | 77 | <  0.01 | 2.31 | 0.02 |
Other regions | 2 | 1.18 (0.87–1.61) | 62 | 0.10 | 1.08 | 0.28 | |
FBXW7 detection method | IHC/qRT-PCR | 6 | 1.39 (1.22–1.59) | 46 | 0.10 | 4.95 | <  0.01 |
Sequencing | 4 | 1.17 (0.94–1.47) | 73 | 0.01 | 1.40 | 0.16 | |
Sample Size | ≥ 100 | 7 | 1.23 (1.01–1.51) | 81 | <  0.01 | 2.06 | 0.04 |
<  100 | 3 | 1.33 (1.09–1.63) | 0 | 0.85 | 2.81 | <  0.01 | |
Data types | Univariate | 7 | 1.13 (0.94–1.35) | 56 | 0.03 | 1.28 | 0.20 |
Multivariate | 3 | 1.47 (1.25–1.74) | 50 | 0.13 | 4.56 | <  0.01 |