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Table 3 Subgroup analyses for overall survival

From: Clinical significance of FBXW7 tumor suppressor gene mutations and expression in human colorectal cancer: a systemic review and meta-analysis

Outcome

Characteristics

Number of studies

HR(95%CI)

I2 (%)

Ph

Z

P value

Recruitment time

Before 2009

5

1.24 (0.93–1.65)

88

<  0.01

1.46

0.14

After 2009

5

1.32 (1.17–1.50)

32

0.21

4.43

<  0.01

Region

Eastern asia

8

1.27 (1.04–1.55)

77

<  0.01

2.31

0.02

Other regions

2

1.18 (0.87–1.61)

62

0.10

1.08

0.28

FBXW7 detection method

IHC/qRT-PCR

6

1.39 (1.22–1.59)

46

0.10

4.95

<  0.01

Sequencing

4

1.17 (0.94–1.47)

73

0.01

1.40

0.16

Sample Size

≥ 100

7

1.23 (1.01–1.51)

81

<  0.01

2.06

0.04

<  100

3

1.33 (1.09–1.63)

0

0.85

2.81

<  0.01

Data types

Univariate

7

1.13 (0.94–1.35)

56

0.03

1.28

0.20

Multivariate

3

1.47 (1.25–1.74)

50

0.13

4.56

<  0.01