Table 2 Meta-analysis of FXBW7 status and clinicopathological features in CRC
Parameters Characteristics | Number of studies | OR (95%CI) | I2 (%) | Ph | Z | P value |
|---|---|---|---|---|---|---|
Age(≥ 60 year vs. <  60 year) | 3 | 1.00 (0.93–1.36) | 0 | 0.71 | 0.00 | 1.00 |
Gender (Male vs. Female) | 7 | 1.03 (0.83–1.28) | 6 | 0.38 | 0.28 | 0.78 |
Differentiation(Well vs. Moderate + Poor) | 2 | 0.81 (0.40–1.64) | 0 | 0.63 | 0.89 | 0.37 |
Differentiation(Well+ Moderate vs. Poor) | 4 | 0.72 (0.35–1.48) | 69 | 0.02 | 0.59 | 0.55 |
Size(≥ 5 cm vs. <  5 cm) | 3 | 0.93 (0.64–1.35) | 0 | 0.45 | 0.37 | 0.71 |
Tumor location(Colon vs. Rectum) | 5 | 0.85 (0.64–1.12) | 30 | 0.22 | 1.17 | 0.24 |
Venous invasion(Present vs. Absent) | 3 | 1.63 (1.01–2.64) | 14 | 0.31 | 1.99 | 0.05 |
Peritoneal metastasis (Present vs. Absent) | 2 | 0.82 (0.38–1.80) | 0 | 0.40 | 0.49 | 0.63 |
Depth of invasion (T1 + T2 vs. T3 + T4) | 3 | 0.44 (0.27–0.74) | 0 | 0.99 | 3.12 | <  0.01 |
Lymph node metastasis (Positive vs. Negative) | 5 | 1.88 (1.40–2.53) | 0 | 0.45 | 4.18 | <  0.01 |
Distant metastasis (Present vs. Absent) | 3 | 1.85 (0.34–10.24) | 92 | <  0.01 | 0.71 | 0.48 |
TNM stage(I + II vs. III + IV) | 3 | 0.53 (0.15–1.84) | 95 | <  0.01 | 1.00 | 0.32 |
Duke’s stage(A + B vs. C + D) | 2 | 0.45 (0.04–5.20) | 90 | <  0.01 | 0.64 | 0.52 |