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Table 2 Distribution of major nucleotide variation in HPV16 E6 and E7 genes based on cervical disease status

From: Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China

Gene

Nucleotide variation

Amino Acid variation

Women with cervical disease status

NILM n = 65

CIN1 n = 22

CIN2 n = 31

CIN3 n = 61

SCC n = 15

Total n = 194

synonymous substitutions

 E6

A95G

R5G

0

1

1

0

0

2

T105G

M8R

0

0

1

1

0

2

C110G

Q10E

1

0

0

0

0

1

A134C

K18Q

0

0

0

0

1

1

T137G

L19V

0

0

0

1

0

1

G145T

Q21H

0

1

0

0

0

1

A152G

T24A

0

0

0

1

0

1

C168G

T29S

0

0

1

0

0

1

T178G

D32E

38

11

18

46

10

123

T178A

D32E

0

2

1

2

0

5

T185G

L35V

0

0

0

1

0

1

G188C

E36Q

0

1

0

0

0

1

A296C

K72Q

0

1

0

0

0

1

T310C

F76L

0

1

1

0

0

2

C335T

H85Y

4

2

3

4

2

15

T350G

L90V

3

2

3

1

0

9

T434G

C118G

0

1

0

0

0

1

A442C

E120D

7

2

2

8

2

21

 E7

A646C

N29F

5

3

4

5

2

19

A647G

N29S

40

11

20

46

10

127

A647C

N29T

0

1

0

0

0

1

C712A

H51N

0

0

0

1

0

1

T730C

F57L

0

0

0

1

0

1

C790T

R77C

7

0

2

3

2

14

G791T

R77L

0

1

0

0

0

1

G823T

G88*

0

1

0

0

0

1

non-synonymous substitutions

 E7

G663A

–

2

1

0

3

0

6

G666A

–

5

5

3

6

0

19

T843C

–

4

1

5

10

1

21

T846C

–

40

11

19

44

10

124

 

others

–

9

6

5

8

1

29

 

Total

 

165

66

89

192

41

553

  1. NILM negative for intraepithelial lesion or malignancy, CIN cervical intraepithelial neoplasia, SCC squamous cell carcinoma
  2. The symbol *reflected terminal codon, the end of the protein sequence