From: Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China
Gene | Nucleotide variation | Amino Acid variation | Women with cervical disease status | |||||
---|---|---|---|---|---|---|---|---|
NILM n = 65 | CIN1 n = 22 | CIN2 n = 31 | CIN3 n = 61 | SCC n = 15 | Total n = 194 | |||
synonymous substitutions | ||||||||
 E6 | A95G | R5G | 0 | 1 | 1 | 0 | 0 | 2 |
T105G | M8R | 0 | 0 | 1 | 1 | 0 | 2 | |
C110G | Q10E | 1 | 0 | 0 | 0 | 0 | 1 | |
A134C | K18Q | 0 | 0 | 0 | 0 | 1 | 1 | |
T137G | L19V | 0 | 0 | 0 | 1 | 0 | 1 | |
G145T | Q21H | 0 | 1 | 0 | 0 | 0 | 1 | |
A152G | T24A | 0 | 0 | 0 | 1 | 0 | 1 | |
C168G | T29S | 0 | 0 | 1 | 0 | 0 | 1 | |
T178G | D32E | 38 | 11 | 18 | 46 | 10 | 123 | |
T178A | D32E | 0 | 2 | 1 | 2 | 0 | 5 | |
T185G | L35V | 0 | 0 | 0 | 1 | 0 | 1 | |
G188C | E36Q | 0 | 1 | 0 | 0 | 0 | 1 | |
A296C | K72Q | 0 | 1 | 0 | 0 | 0 | 1 | |
T310C | F76L | 0 | 1 | 1 | 0 | 0 | 2 | |
C335T | H85Y | 4 | 2 | 3 | 4 | 2 | 15 | |
T350G | L90V | 3 | 2 | 3 | 1 | 0 | 9 | |
T434G | C118G | 0 | 1 | 0 | 0 | 0 | 1 | |
A442C | E120D | 7 | 2 | 2 | 8 | 2 | 21 | |
 E7 | A646C | N29F | 5 | 3 | 4 | 5 | 2 | 19 |
A647G | N29S | 40 | 11 | 20 | 46 | 10 | 127 | |
A647C | N29T | 0 | 1 | 0 | 0 | 0 | 1 | |
C712A | H51N | 0 | 0 | 0 | 1 | 0 | 1 | |
T730C | F57L | 0 | 0 | 0 | 1 | 0 | 1 | |
C790T | R77C | 7 | 0 | 2 | 3 | 2 | 14 | |
G791T | R77L | 0 | 1 | 0 | 0 | 0 | 1 | |
G823T | G88* | 0 | 1 | 0 | 0 | 0 | 1 | |
non-synonymous substitutions | ||||||||
 E7 | G663A | – | 2 | 1 | 0 | 3 | 0 | 6 |
G666A | – | 5 | 5 | 3 | 6 | 0 | 19 | |
T843C | – | 4 | 1 | 5 | 10 | 1 | 21 | |
T846C | – | 40 | 11 | 19 | 44 | 10 | 124 | |
 | others | – | 9 | 6 | 5 | 8 | 1 | 29 |
 | Total |  | 165 | 66 | 89 | 192 | 41 | 553 |