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Fig. 4 | BMC Cancer

Fig. 4

From: Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression

Fig. 4

The abundance of monocyte-derived cells relative to total immune cells is positively associated with the CAPRA-S risk score and negatively associated with disease-free survival. Association of monocyte-derived cell abundance (see Materials and Methods) with disease-free survival in the independent primary prostate cancer TCGA dataset (n = 134). A Polar plot of differential tissue composition of primary prostate cancer TCGA samples for which CAPRA-S risk score information is available, with the factor of interest being CAPRA-S risk score. The y-axis (scaled by the fourth root) represents the overall cell type abundance; the colour coding reflects the association between cell type abundance and disease-free survival (coloured = significant association). B Kaplan–Meier plot of patients (n = 134) with low (blue) or high (red) monocyte-derived cell infiltration in the tumour specimen (proportion cut-off = 0.0048; see Materials and Methods section, Survival analyses subsection). C Kaplan–Meier plot for the other cell types included in the analysis

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