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Table 3 Acute adverse effects for patients treated with adjuvant EBRT with/or VBT

From: Treatment optimization of pelvic external beam radiation and/or vaginal brachytherapy for patients with stage I to II high-risk Endometrioid adenocarcinoma: a retrospective multi-institutional analysis

 

Patients (N = 218)

EBRT (n = 51)

VBT (n = 25)

EBRT + VBT (n = 142)

p-value

Adverse Events

No. (%)

No. (%)

No. (%)

 

bUpper GI

   

0.001

 0

36 (70.6)

21 (84.0) a2.5

77 (54.2) a-3.0

 

 1–2

15 (29.4)

3 (12.0) a-2.9

65 (45.8) a3.2

 

 3

0 (0.0)

1 (4.0) a2.8

0 (0.0)

 

bLower GI

   

0.000

 0

27 (52.9)

22 (88.0) a4.7

48 (33.8) a-4.3

 

 1–2

23 (45.1)

3 (12.0) a-4.5

93 (65.5) a4.4

 

 3

1 (2.0)

0 (0.0)

1 (0.7)

 

Urinary Tract

   

0.864

 0

44 (86.3)

23 (92.0)

123 (86.6)

 

 1–2

7 (13.7)

2 (8.0)

18 (12.7)

 

 3

0 (0.0)

0 (0.0)

1 (0.7)

 

Hematological

   

0.023

 0

23 (45.1)

21 (84.0) a3.1

75 (52.8)

 

 1–2

25 (49.0)

4 (16.0) a-2.7

60 (42.3)

 

 3–4

3 (5.9)

0 (0.0)

7 (4.9)

 
  1. Abbreviation: GI gastrointestinal, EBRT External Beam Radiation, VBT Vaginal Brachytherapy
  2. a adjusted residuals, only value greater than ±2 were marked. b Upper GI toxicity defined in this study included nausea and vomiting; Lower GI reactions included diarrhea, constipation, abdominal pain et al