Effect of cachexia on bone turnover in cancer patients: a case-control study

BMC Cancer

Table 4 Variables associated with a negative bone turnover balance in cancer patients (n = 52)

	All patients (*n =* 52)			Patients without bone metastases (n = 44)
	OR	CI	p	OR	CI	p
CTX/Ocn ratio > 0.022^a
Hypoalbuminemia	19.8	3.5–111.5	*0.001*	10.5	1.6–65.6	*0.01*
High CRP	4.56	1–20	0.05	7.6	1.5–38.4	*0.01*
Adjusted R squared	0.54			0.52
CTX/PINP ratio > 0.011^b
High CRP	5.29	1.6–17.5	*0.006*	7.7	1.9–30.5	*0.003*
Adjusted R squared	0.2			0.3

Abbreviations: OR odds ratio, CI confidence interval, CRP C-reactive protein, CTX carboxy terminal telopeptide of collagen type I, Ocn osteocalcin, PINP procollagen type I N-terminal propeptides
- The backward stepwise regression models included:
^aBMI, body weight loss (weight loss > 0%), hypoalbuminemia (albumin < 35 g/L), high CRP (CRP > 1 mg/dL), anemia (hemoglobin < 12,5 g/dL), phase angle, eGFR adjusted for age.
^bBody weight loss (weight loss > 0%), hypoalbuminemia (albumin < 35 g/L), high CRP (CRP > 1 mg/dL), adjusted for age.

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