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Table 4 Variables associated with a negative bone turnover balance in cancer patients (n = 52)

From: Effect of cachexia on bone turnover in cancer patients: a case-control study

  All patients (n = 52) Patients without bone metastases (n = 44)
OR CI p OR CI p
CTX/Ocn ratio > 0.022a
 Hypoalbuminemia 19.8 3.5–111.5 0.001 10.5 1.6–65.6 0.01
 High CRP 4.56 1–20 0.05 7.6 1.5–38.4 0.01
 Adjusted R squared 0.54    0.52   
CTX/PINP ratio > 0.011b
 High CRP 5.29 1.6–17.5 0.006 7.7 1.9–30.5 0.003
 Adjusted R squared 0.2    0.3   
  1. Abbreviations: OR odds ratio, CI confidence interval, CRP C-reactive protein, CTX carboxy terminal telopeptide of collagen type I, Ocn osteocalcin, PINP procollagen type I N-terminal propeptides
  2. - The backward stepwise regression models included:
  3. aBMI, body weight loss (weight loss > 0%), hypoalbuminemia (albumin < 35 g/L), high CRP (CRP > 1 mg/dL), anemia (hemoglobin < 12,5 g/dL), phase angle, eGFR adjusted for age.
  4. bBody weight loss (weight loss > 0%), hypoalbuminemia (albumin < 35 g/L), high CRP (CRP > 1 mg/dL), adjusted for age.