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Table 1 Characteristics of patients in the whole cohort

From: The value of the tumour-stroma ratio for predicting neoadjuvant chemoradiotherapy response in locally advanced rectal cancer: a case control study

 

Total

Major-responders

Non-responders

P

N = 248

N = 102

N = 146

Age (year, mean ± SD)

54.61 ± 11.61

54.20 ± 11.17

55.20 ± 12.25

0.514

Sex

   

0.548

 Male

176 (71.0%)

101 (69.2%)

75 (73.5%)

 

 Female

72 (29.0%)

45 (30.8%)

27 (26.5%)

 

Histopathological type

   

0.793

 Adenocarcinoma

236 (95.2%)

138 (94.5%)

98 (96.1%)

 

 Mucinous adenocarcinoma

12 (4.8%)

8 (5.5%)

4 (3.9%)

 

Differentiation grade

   

0.274

 Well or moderate

232 (93.5%)

134 (91.8%)

98 (96.1%)

 

 Poor

16 (6.5%)

12 (8.2%)

4 (3.9%)

 

cT status

   

0.657

 cT2

10 (4.0%)

6 (4.1%)

4 (4.0%)

 

 cT3

175 (70.6%)

106 (72.6%)

69 (67.6%)

 

 cT4

63 (25.4%)

34 (23.3%)

29 (28.4%)

 

cN status

   

0.07

 cN0

38 (15.3%)

19 (13.0%)

19 (18.6%)

 

 cN1

101 (40.7%)

54 (37.0%)

47 (46.1%)

 

 cN2

109 (44.0%)

73 (50.0%)

36 (35.3%)

 

Tumour location

   

0.787

 < 5 cm

140 (56.5%)

85 (58.2%)

55 (53.9%)

 

 5–10 cm

103 (41.5%)

58 (39.7%)

45 (44.1%)

 

 > 10 cm

5 (2.0%)

3 (2.1%)

2 (2.0%)

 

CEA level

   

0.731

 Normal

143 (57.7%)

86 (58.9%)

57 (55.9%)

 

 Abnormal

105 (42.3%)

60 (41.1%)

45 (44.1%)

 

CA199 level

   

0.550

 Normal

196 (79.0%)

113 (77.4%)

83 (81.4%)

 

 Abnormal

52 (21.0%)

33 (22.6%)

19 (18.6%)

 

Chemotherapeutic regimen

   

0.001

 5-fluorouracil

35 (14.1%)

16 (11.0%)

19 (18.6%)

 

 Capecitabine

33 (13.3%)

10 (6.8%)

23 (22.5%)

 

 FOLFOX

150 (60.5%)

104 (71.2%)

46 (45.1%)

 

 Other regimens

30 (12.1%)

16 (11.0%)

14 (81.4%)

 

Time interval between nCRT and surgery

   

0.046

 < 7 weeks

13 (5.3%)

4 (2.8%)

9 (8.8%)

 

 7–10 weeks

91 (36.8%)

50 (34.5%)

41 (40.2%)

 

 > 10 weeks

143 (57.9%)

91 (62.8%)

52 (51.0%)

 

Neoadjuvant radiotherapy dose

   

0.012

 < 45 Gy

20 (8.1%)

6 (4.1%)

14 (13.7%)

 

 ≥ 45 Gy

228 (91.9%)

140 (95.9%)

88 (86.3%)

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