Table 4 Univariate Logistic Regression models for relative risk of select individual treatment and toxicity related outcomes according to PI use
Outcome | Taking a Protease Inhibitor Odds Ratio (95% CI) | p-value |
|---|---|---|
Treatment-related | ||
 Completed Radiation | 0.71 (0.27–1.86) | 0.48 |
 Length of Radiation Treatment > 50 days | 0.74 (0.40–1.36) | 0.33 |
 Required a Chemotherapy Dose Reduction | 1.47 (0.76–2.84) | 0.25 |
Toxicities during treatment | ||
 Hospitalized for GI Toxicity | 1.01 (0.25–4.02) | 0.99 |
 Hospitalized for Hematologic Toxicity | 4.60 (1.56–13.5) | < 0.01 |
 Hospitalized for Febrile Neutropenia | 6.25 (1.44–27.2) | 0.01 |
 Hospitalized for Radiation Dermatitis | 0.74 (0.21–2.63) | 0.65 |
 Acute Radiation Dermatitis at least Grade 3 | 0.94 (0.51–1.74) | 0.85 |
 Acute GI Toxicity at least Grade 3 | 1.94 (0.70–5.39) | 0.20 |
 Acute Oral Mucositis at least Grade 3 | 1.04 (0.35–3.07) | 0.95 |
 Late GI Toxicity at least Grade 3 | 1.56 (0.49–4.93) | 0.45 |
 Other Late Toxicity at least Grade 3 | 0.63 (0.17–2.32) | 0.49 |
 Any Acute Hematologic Toxicity | 2.12 (1.18–3.83) | 0.01 |
 Acute Anemia at least Grade 3 | 1.47 (0.39–5.52) | 0.57 |
 Acute Leukopenia at least Grade 3 | 1.73 (0.93–3.23) | 0.08 |
 Acute Thrombocytopenia at least Grade 3 | 1.54 (0.71–3.34) | 0.28 |
 Acute Neutropenia at least Grade 3 | 1.73 (0.71–4.20) | 0.23 |
 Acute Lymphopenia at least Grade 3 | 1.92 (1.05–3.51) | 0.03 |