Table 6 Functional and pathway enrichment analysis
Category | ID | Term Description | Observed gene count | Background gene count | P-value | Included Gene |
|---|---|---|---|---|---|---|
Biological Process (GO) | GO:0007166 | Cell Surface Receptor Signaling Pathway | 31 | 2198 | 2.11E-23 | BTK,CCR2,KLRG1 |
GO:0002376 | Immune System Process | 28 | 2370 | 2.94E-18 | BTK,CCR2,KLRG1 | |
GO:0007165 | Signal Transduction | 32 | 4738 | 1.10E-15 | BTK,CCR2,KLRG1 | |
GO:0006955 | Immune Response | 23 | 1560 | 1.11E-15 | BTK,CCR2,KLRG1 | |
GO:0051716 | Cellular Response to Stimulus | 33 | 6212 | 7.71E-14 | BTK,CCR2,KLRG1 | |
GO:0006952 | Defense Response | 18 | 1234 | 1.82E-11 | BTK,CCR2,KLRG1 | |
GO:0045087 | Innate Immune Response | 14 | 676 | 1.68E-10 | BTK,KLRG1 | |
GO:0006950 | Response to Stress | 22 | 3267 | 1.95E-08 | BTK,CCR2,KLRG1 | |
GO:0050794 | Regulation of Cellular Process | 34 | 10,484 | 2.12E-08 | BTK,CCR2,KLRG1,SCML4 | |
GO:0006954 | Inflammatory Response | 9 | 482 | 2.51E-06 | BTK,CCR2,KLRG1 | |
Molecular Function (GO) | GO:0005515 | Protein Binding | 29 | 6605 | 1.32E-07 | BTK,CCR2 |
GO:0005102 | Signaling Receptor Binding | 15 | 1513 | 7.57E-07 | BTK,CCR2 | |
GO:0005488 | Binding | 31 | 11,878 | 0.001 | BTK,CCR2,KLRG1 | |
GO:0042802 | Identical Protein Binding | 9 | 1754 | 0.0128 | BTK,CCR2 | |
Cellular Component (GO) | GO:0071944 | Cell Periphery | 23 | 5254 | 2.02E-05 | BTK,CCR2,KLRG1 |
GO:0005886 | Plasma Membrane | 22 | 5159 | 5.39E-05 | BTK,CCR2,KLRG1 | |
GO:0005623 | Cell | 34 | 16,271 | 0.011 | BTK,CCR2,KLRG1,SCML4 | |
GO:0016020 | Membrane | 23 | 8420 | 0.0169 | BTK,CCR2,KLRG1 | |
GO:0005622 | Intracellular | 31 | 14,286 | 0.037 | BTK,CCR2,KLRG1,SCML4 | |
KEGG Pathways | hsa04662 | B Cell Receptor Signaling Pathway | 8 | 71 | 3.96E-11 | BTK |
hsa04062 | Chemokine Signaling Pathway | 8 | 181 | 2.36E-08 | CCR2 | |
hsa04664 | Fc Epsilon Ri Signaling Pathway | 6 | 67 | 5.25E-08 | BTK | |
hsa05340 | Primary Immunodeficiency | 5 | 37 | 1.53E-07 | BTK | |
Reactome Pathways | HSA-168256 | Immune System | 27 | 1925 | 4.00E-19 | BTK,CCR2,KLRG1 |
HSA-1280218 | Adaptive Immune System | 16 | 733 | 8.03E-13 | BTK,KLRG1 | |
HSA-168249 | Innate Immune System | 17 | 1012 | 5.02E-12 | BTK,CCR2 | |
HSA-162582 | Signal Transduction | 22 | 2605 | 1.53E-10 | BTK,CCR2 | |
UniProt Keywords | KW-0391 | Immunity | 8 | 507 | 5.56E-05 | BTK,KLRG1 |
KW-1003 | Cell Membrane | 16 | 3208 | 0.00064 | BTK,CCR2,KLRG1 | |
KW-0597 | Phosphoprotein | 25 | 8066 | 0.0018 | BTK,CCR2,SCML4 | |
KW-0399 | Innate Immunity | 4 | 309 | 0.0141 | BTK,KLRG1 |