Fig. 6

The interaction between KLRG1, BTK and CCR2 influences the proliferation of lung tumor cells. A Protein-protein interaction analysis of KLRG1, BTK, CCR2, SCML4 and their-related genes. Each node represents a different gene. Each line represents a connection between two different genes. B-D The expression of BTK (B), CCR2 (C) and SCML4 (D) in KLRG1-knockdown A549 tumor cells were evaluated by qRT-PCR, n = 3 for each group, P values are derived from two-tailed unpaired Student’s t-test. E The effect of E-Cadherin antibody or IgG1 treatment on the proliferation of A549 tumor cells treated with scramble or KLRG1 shRNA, n = 4 for each group, P values are derived from two-tailed unpaired Student’s t-test. F-G Regression analysis of the correlation between KLRG1 and IFNG (F) or CD274 (G), P values are derived from Spearman and Pearson correlation analysis. Data represent mean ± SD. **, P < 0.01, ***, P < 0.001, ns, no significance