Variable | IDS + HIPEC (n = 121) | IDS alone (n = 76) | p-value |
---|---|---|---|
Demographic mean (SD) | |||
 Age | 58.38 (10.89) | 55.20 (10.87) | 0.337ª |
 BMI (kg/m2) (SD) | 26.77 (2.78) | 26.65 (2.40) | 0.277ª |
Neo-adjuvant chemotherapy cycles, n (%) | Â | Â | 0.442b |
 Two cycles | 28 (23.1) | 20 (26.3) |  |
 Three cycles | 74 (61.2) | 47 (61.8) |  |
 Four cycles | 19 (15.7) | 9 (11.8) |  |
Cyto-reductive surgery, n (%) | Â | Â | 0.734b |
 Optimal (R0 + R1) | 113 (93.4) | 70 (92.1) |  |
 Sub-optimal (residual disease > 1 cm) | 8 (6.6) | 6 (7.9) |  |
Bowel resection, n (%) | Â | Â | 0.523b |
 No bowel resection performed | 101 (83.5) | 66 (86.8) |  |
 Bowel resection performed | 20 (16.5) | 10 (13.2) |  |
Mean duration of hospitalization-days (SD) after surgery | 8.91 (1.89) | 8.07 (1.80) | 0.001a |
Median time to postoperative systemic treatment with chemotherapy (SD) | 22 (2.37) | 15 (1.87) | 0.001a |
Performance status (ECOG), n (%) | Â | Â | 0.980b |
 0 | 38 (31.4) | 24 (31.6) |  |
 1 | 83 (68.6) | 52 (68.4) |  |
TC chemotherapy cycles after IDS (%) | Â | Â | 0.015b |
 3 cycles | 6 (5.0) | 5 (6.6) |  |
 4 cycles | 58 (47.9) | 49 (64.5) |  |
 5 cycles | 57 (47.1) | 22 (28.9) |  |
Total of TC cycles (SD) | 6.73 (0.53) | 6.48 (0.66) | 0.047b |