|  | Univariate cox | Multivariate cox | ||||
---|---|---|---|---|---|---|---|
 | HR | 95%CI | P-value | HR | 95%CI | P-value | |
Marital status | Married | Reference | Â | Â | Â | ||
Separated | 1.25 | 1.07–1.47 | 0.006 | 1.25 | 1.06–1.47 | 0.009 | |
Single | 1.28 | 1.09–1.5 | 0.003 | 1.35 | 1.15–1.60 | < 0.001 | |
Age | < 65 | Reference |  |  |  | ||
65–75 | 1.15 | 0.99–1.33 | 0.072 | 1.26 | 1.08–1.47 | 0.004 | |
> 75 | 1.79 | 1.47–2.19 | < 0.001 | 1.98 | 1.61–2.43 | < 0.001 | |
Race | Other | Reference | Â | Â | Â | ||
White | 1.75 | 1.47–2.08 | < 0.001 | 1.75 | 1.46–2.09 | < 0.001 | |
Black | 1.5 | 1.18–1.92 | 0.001 | 1.41 | 1.09–1.81 | 0.008 | |
Sex | female | Reference | Â | Â | Â | ||
male | 1.04 | 0.89–1.21 | 0.632 |  |  |  | |
Histological grade | Well differentiated | Reference | Â | Â | Â | ||
Moderately differentiated | 1.23 | 0.98–1.54 | 0.077 | 1.19 | 0.95–1.50 | 0.131 | |
Poorly differentiated | 1.55 | 1.11–2.18 | 0.01 | 1.49 | 1.06–2.10 | 0.023 | |
Undifferentiated | 4.19 | 1.33–13.18 | 0.014 | 2.54 | 0.80–8.10 | 0.115 | |
unknown | 1.16 | 0.96–1.41 | 0.128 | 1.25 | 1.03–1.52 | 0.024 | |
T | T1a | Reference | Â | Â | Â | ||
T1b | 1.54 | 1.22–1.94 | < 0.001 | 1.08 | 0.83–1.39 | 0.574 | |
T2 | 1.94 | 1.52–2.47 | < 0.001 | 1.39 | 1.07–1.80 | 0.013 | |
T3 | 3.83 | 2.73–5.37 | < 0.001 | 1.63 | 1.11–2.39 | 0.013 | |
T4 | 5.34 | 3.52–8.11 | < 0.001 | 2.40 | 1.54–3.73 | < 0.001 | |
N | N0 | Reference | Â | Â | Â | ||
N1 | 1.49 | 0.97–2.3 | 0.071 |  |  |  | |
M | M0 | Reference | Â | Â | Â | ||
M1 | 2.21 | 1.33–3.69 | 0.002 | 1.65 | 0.97–2.81 | 0.063 | |
Radiation therapy | Unradiation | Reference | Â | Â | Â | ||
Radiation | 1.64 | 1.13–2.38 | 0.009 | 1.03 | 0.70–1.52 | 0.865 | |
Chemotherapy | Unchemotherapy | Reference | Â | Â | Â | ||
chemotherapy | 1.1 | 0.96–1.26 | 0.168 |  |  |  | |
Tumor size | 0-28 mm | Reference |  |  |  | ||
28-35 mm | 1.31 | 1.09–1.56 | 0.003 | 1.33 | 1.10–1.60 | 0.004 | |
> 35 mm | 2.35 | 2.03–2.72 | < 0.001 | 2.16 | 1.83–2.56 | < 0.001 | |
Afp | nomal-afp | Reference | Â | Â | Â | ||
up-afp | 1.42 | 1.22–1.64 | < 0.001 | 1.44 | 1.24–1.67 | < 0.001 | |
Fibersis | non-fibersis | Reference | Â | Â | Â | ||
fibersis | 1.05 | 0.8–1.4 | 0.709 |  |  |  | |
unknown | 1.15 | 0.88–1.51 | 0.294 |  |  |  |