Table 3 Risk factors correlated with cancer-specific survival in all appendiceal cancer patients

  ≤ 56

1

1

1

1

  > 56

1.46 (1.3–1.64)

<.0001

1.19 (1.05–1.34)

0.0054

1.99 (1.8–2.19)

<.0001

1.61 (1.45–1.78)

<.0001

 Male

1

1

1

 Female

1.06 (0.94–1.19)

0.3459

0.92 (0.84–1.01)

0.0715

0.82 (0.74–0.9)

<.0001

 Married

1

1

1

1

 Unmarried^a

1.04 (0.92–1.18)

0.507

1.24 (1.09–1.4)

0.0008

1.17 (1.07–1.29)

0.0011

1.35 (1.22–1.49)

<.0001

 Unknown

0.78 (0.58–1.06)

0.1106

1.3 (0.96–1.77)

0.092

0.84 (0.66–1.07)

0.1632

1.28 (1–1.63)

0.0501

 African American

1

1

1

1

 White

0.72 (0.6–0.85)

0.0002

0.75 (0.62–0.9)

0.0017

0.75 (0.65–0.86)

<.0001

0.82 (0.71–0.95)

0.0068

 Other

0.9 (0.69–1.18)

0.447

0.77 (0.58–1.02)

0.0728

0.82 (0.65–1.02)

0.0744

0.8 (0.63–1.02)

0.0657

 Unknown

0.16 (0.04–0.64)

0.0098

0.39 (0.1–1.6)

0.1928

0.16 (0.05–0.49)

0.0014

0.33 (0.11–1.04)

0.0592

 West

1

1

1

1

 South

1.16 (1.01–1.34)

0.0397

1.22 (1.05–1.42)

0.01

1.16 (1.03–1.3)

0.0124

1.2 (1.06–1.35)

0.0034

 Midwest

1.38 (1.14–1.67)

0.0008

1.22 (1–1.49)

0.0478

1.29 (1.1–1.51)

0.0014

1.18 (1–1.39)

0.0475

 Northwest

0.93 (0.79–1.1)

0.3925

1.03 (0.87–1.21)

0.7785

0.98 (0.86–1.12)

0.7558

1.06 (0.93–1.21)

0.3898

 Negative

1

1

1

1

 Positive

1.82 (1.54–2.15)

<.0001

1.4 (1.17–1.67)

0.0006

1.67 (1.45–1.93)

<.0001

1.33 (1.14–1.54)

0.0002

 Unknown

0.53 (0.45–0.61)

<.0001

0.97 (0.83–1.14)

0.7777

0.63 (0.55–0.71)

<.0001

0.99 (0.87–1.13)

0.909

 Negative

1

1

1

1

 Positive

4.21 (3.49–5.07)

<.0001

1.31 (1.07–1.6)

0.008

3.36 (2.88–3.92)

<.0001

1.36 (1.15–1.61)

0.0003

 Unknown

1.15 (1–1.32)

0.0431

1.37 (1.19–1.58)

<.0001

1.04 (0.93–1.16)

0.4885

1.22 (1.09–1.37)

0.0007

  < 2 cm

1

1

1

1

 2–2.9 cm

3.45 (2.64–4.5)

<.0001

1.23 (0.93–1.62)

0.1461

2.18 (1.8–2.65)

<.0001

1.12 (0.91–1.38)

0.2898

  ≤ 3 cm

5.2 (4.2–6.42)

<.0001

1.33 (1.06–1.67)

0.0143

3.19 (2.76–3.69)

<.0001

1.25 (1.06–1.47)

0.0085

 Unknown

4.53 (3.64–5.65)

<.0001

1.33 (1.06–1.69)

0.0163

2.87 (2.46–3.34)

<.0001

1.24 (1.05–1.47)

0.0132

  ≤ 12

1

1

1

1

  > 12

0.88 (0.78–0.99)

0.0318

0.58 (0.51–0.66)

<.0001

0.82 (0.75–0.91)

<.0001

0.61 (0.55–0.68)

<.0001

 Unknown

1.76 (1.14–2.72)

0.0108

0.85 (0.55–1.32)

0.5551

1.46 (1–2.12)

0.0501

0.82 (0.56–1.2)

0.2969

 GCC

1

1

1

1

 MAC

2.39 (1.85–3.09)

<.0001

1.31 (0.99–1.74)

0.0609

1.81 (1.5–2.19)

<.0001

1.16 (0.94–1.43)

0.1765

 NMAC

3.59 (2.77–4.67)

<.0001

2.26 (1.71–2.99)

<.0001

2.91 (2.4–3.53)

<.0001

2.05 (1.66–2.53)

<.0001

 SRCC

6.81 (5.16–8.99)

<.0001

1.89 (1.4–2.55)

<.0001

4.63 (3.75–5.71)

<.0001

1.78 (1.41–2.24)

<.0001

 NECs

0.42 (0.23–0.74)

0.0027

0.76 (0.42–1.4)

0.3776

0.63 (0.44–0.89)

0.0093

0.95 (0.65–1.39)

0.7755

 NETs

0.12 (0.06–0.23)

<.0001

0.32 (0.16–0.65)

0.0017

0.35 (0.26–0.48)

<.0001

0.64 (0.45–0.92)

0.0171

 MiNENs

3.03 (2.18–4.2)

<.0001

1.72 (1.23–2.41)

0.0016

2.08 (1.61–2.7)

<.0001

1.4 (1.07–1.83)

0.0137

 T1

1

1

1

1

 T2

1.54 (0.96–2.46)

0.0741

0.77 (0.47–1.24)

0.2788

1.34 (1.03–1.76)

0.0327

0.79 (0.59–1.05)

0.1077

 T3

4.51 (3.32–6.13)

<.0001

1.51 (1.08–2.12)

0.0165

2.38 (1.99–2.85)

<.0001

1.15 (0.93–1.43)

0.1923

 T4

12.72 (9.5–17.02)

<.0001

2.38 (1.71–3.32)

<.0001

5.2 (4.4–6.15)

<.0001

1.69 (1.37–2.09)

<.0001

 N0

1

1

1

1

 N1

3.14 (2.72–3.62)

<.0001

2.26 (1.93–2.65)

<.0001

2.32 (2.06–2.61)

<.0001

2 (1.75–2.28)

<.0001

 N2

8.15 (7.05–9.42)

<.0001

3.03 (2.53–3.62)

<.0001

5.8 (5.14–6.56)

<.0001

2.89 (2.48–3.37)

<.0001

 M0

1

1

1

1

 M1

5.46 (4.85–6.16)

<.0001

2.45 (2.1–2.86)

<.0001

3.47 (3.16–3.81)

<.0001

2.04 (1.8–2.31)

<.0001

 Well differentiated

1

1

1

1

 Moderately differentiated

2.83 (2.33–3.44)

<.0001

1.62 (1.32–1.99)

<.0001

2.32 (2.01–2.67)

<.0001

1.49 (1.28–1.73)

<.0001

 Poorly or un-differentiated

8.52 (7.08–10.26)

<.0001

2.73 (2.2–3.39)

<.0001

5.44 (4.73–6.25)

<.0001

2.21 (1.87–2.62)

<.0001

 Unknown

2.53 (2.05–3.11)

<.0001

2.16 (1.73–2.69)

<.0001

2.08 (1.78–2.42)

<.0001

1.71 (1.45–2.02)

<.0001

 Less than hemicolectomy

1

1

1

 Hemicolectomy or more

1.43 (1.26–1.63)

<.0001

1.22 (1.11–1.35)

<.0001

0.89 (0.8–0.98)

0.024

 Other

2.88 (2.36–3.52)

<.0001

2.16 (1.82–2.56)

<.0001

1.51 (1.26–1.81)

<.0001

 No

1

1

1

1

 Yes

3.54 (3.14–3.99)

<.0001

0.93 (0.8–1.07)

0.2983

2.11 (1.93–2.32)

<.0001

0.73 (0.65–0.82)

<.0001