Table 1 Characteristics of appendiceal cancer patients treated with or without chemotherapy in 1998–2016
Variable | All ptients | Chemotherapy status | P value | |
|---|---|---|---|---|
(n = 8733) | No (n = 5957) | Yes (n = 2776) |  | |
Age | ||||
 Mean ± SD | 56.3 ± 16.4 | 56.2 ± 18 | 56.6 ± 12.3 | < 0.0001 |
 Median (range) | 57 (18–99) | 57 (18–99) | 57 (19–89) |  |
  ≤ 56 | 5075 (58.1) | 2885 (48.4) | 1351 (48.7) | 0.4273 |
  > 56 | 3658 (41.9) | 3072 (51.6) | 1425 (51.3) |  |
Gender | ||||
 Male | 3947 (45.2) | 3276 (68.5) | 1510 (31.6) | 0.0603 |
 Female | 4786 (54.8) | 2681 (67.9) | 1266 (32.1) |  |
Marital status | ||||
 Marrieda | 5067 (58) | 3215 (63.5) | 1852 (36.6) | < 0.0001 |
 Unmarried | 3262 (37.4) | 2423 (74.3) | 839 (25.7) |  |
 Unknown | 404 (4.6) | 319 (79) | 85 (21) |  |
Race | ||||
 African American | 854 (9.8) | 576 (67.5) | 278 (32.6) | 0.0001 |
 White | 7299 (83.6) | 4994 (68.4) | 2305 (31.6) |  |
 Other | 515 (5.9) | 328 (63.7) | 187 (36.3) |  |
 Unknown | 65 (0.7) | 59 (90.8) | 6 (9.2) |  |
Region | ||||
 West | 4185 (47.9) | 2899 (69.3) | 1286 (30.7) | 0.0803 |
 South | 2078 (23.8) | 1410 (67.9) | 668 (32.2) |  |
 Midwest | 824 (9.4) | 535 (64.9) | 289 (35.1) |  |
 Northwest | 1646 (18.9) | 1113 (67.6) | 533 (32.4) |  |
CEA | ||||
 Negative | 1126 (12.9) | 513 (45.6) | 613 (54.4) | < 0.0001 |
 Positive | 1097 (12.6) | 430 (39.2) | 667 (60.8) |  |
 Unknown | 6510 (74.5) | 5014 (77) | 1496 (23) |  |
Tumor deposit | ||||
 Negative | 2222 (25.4) | 1391 (62.6) | 831 (37.4) | < 0.0001 |
 Positive | 438 (5) | 128 (29.2) | 310 (70.8) |  |
 Unknown | 6073 (69.5) | 4438 (73.1) | 1635 (26.9) |  |
Tumor size | ||||
  < 2 cm | 2742 (31.4) | 2467 (90) | 275 (10) | < 0.0001 |
  ≥ 2 cm | 3668 (42) | 2086 (56.9) | 1582 (43.1) |  |
 Unknown | 2323 (26.6) | 1404 (60.4) | 919 (39.6) |  |
Harvested lymph nodes | ||||
  ≤ 12 | 5098 (58.4) | 3804 (74.6) | 1294 (25.4) | < 0.0001 |
  > 12 | 3527 (40.4) | 2093 (59.3) | 1434 (40.7) |  |
 Unknown | 108 (1.2) | 60 (55.6) | 48 (44.4) |  |
Histology | ||||
 GCC | 1087 (12.5) | 927 (85.3) | 160 (14.7) | < 0.0001 |
 MAC | 2831 (32.4) | 1518 (53.6) | 1313 (46.4) |  |
 NMAC | 1762 (20.2) | 1046 (59.4) | 716 (40.6) |  |
 SRCC | 575 (6.6) | 207 (36) | 368 (64) |  |
 NECs | 421 (4.8) | 400 (95) | 21 (5) |  |
 NETs | 1667 (19.1) | 1640 (98.4) | 27 (1.6) |  |
 MiNENs | 390 (4.5) | 219 (56.2) | 171 (43.9) |  |
T stage | ||||
 T1 | 2224 (25.5) | 2122 (35.6) | 102 (3.7) | < 0.0001 |
 T2 | 748 (8.6) | 682 (11.5) | 66 (2.4) |  |
 T3 | 2680 (30.7) | 1904 (32) | 776 (28) |  |
 T4 | 3081 (35.3) | 1249 (21) | 1832 (66) |  |
N stage | ||||
 N0 | 6984 (80) | 5293 (88.9) | 1691 (60.9) | < 0.0001 |
 N1 | 1096 (12.6) | 454 (7.6) | 642 (23.1) |  |
 N2 | 653 (7.5) | 210 (3.5) | 443 (16) |  |
M stage | ||||
 M0 | 6604 (75.6) | 5267 (79.8) | 1337 (20.3) | < 0.0001 |
 M1 | 2129 (24.4) | 690 (32.4) | 1439 (67.6) |  |
Grade | ||||
 Well differentiated | 3015 (34.5) | 2475 (82.1) | 540 (17.9) | < 0.0001 |
 Moderately differentiated | 2320 (26.6) | 1411 (60.8) | 909 (39.2) |  |
 Poorly or un-differentiated | 1403 (16.1) | 576 (41.1) | 827 (59) |  |
 Unknown | 1995 (22.8) | 1495 (74.9) | 500 (25.1) |  |
Surgery | ||||
 Less than hemicolectomy | 3847 (44.1) | 3075 (79.9) | 772 (20.1) | < 0.0001 |
 Hemicolectomy or more | 4406 (50.5) | 2600 (59) | 1806 (41) |  |
 Other | 480 (5.5) | 282 (58.8) | 198 (41.3) |  |
Cancer specific death | ||||
 No | 7024 (80.4) | 5232 (74.5) | 1792 (25.5) | < 0.0001 |
 Yes | 1709 (19.6) | 725 (42.4) | 984 (57.6) |  |
Overall death | ||||
 No | 6000 (68.7) | 4456 (74.3) | 1544 (25.7) | < 0.0001 |
 Yes | 2733 (31.3) | 1501 (54.9) | 1232 (45.1) |  |