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Table 3 Risk of Myocardial Infarct, Stroke, and Mortality According to the Age of Diagnosis in the DCIS group

From: Cardiovascular events and mortality in a population-based cohort initially diagnosed with ductal carcinoma in situ

  

Total N

Events (n)

Follow-up Duration (Person-Year)

Incidence rate per 1000

Model 1a

HR (95% CI)

Model 2b

HR (95% CI)

Model 3c

HR (95% CI)

Model 4d

HR (95% CI)

Myocardial Infarct

< 50 years old

 Control group

25,560

67

130,119

0.515

1

1

1

1

 Pure DCIS

3837

9

18,966

0.475

0.92 (0.46, 1.85)

0.92 (0.46, 1.85)

0.97 (0.48, 1.95)

0.91 (0.45, 1.84)

 DCIS+Invasive

4683

5

24,281

0.206

0.40 (0.16, 0.99)

0.40 (0.16, 0.99)

0.41 (0.17, 1.03)

0.29 (0.11, 0.80)

≥50 years old

 Control group

15,660

126

75,381

1.671

1

1

1

1

 Pure DCIS

2347

11

11,137

0.988

0.59 (0.32, 1.10)

0.57 (0.31, 1.06)

0.56 (0.30, 1.03)

0.51 (0.27, 0.95)

 DCIS+Invasive

2873

16

14,025

1.141

0.68 (0.41, 1.15)

0.70 (0.42, 1.18)

0.68 (0.40, 1.14)

0.48 (0.27, 0.85)

Stroke

< 50 years old

 Control group

25,560

97

130,071

0.746

1

1

1

1

 Pure DCIS

3837

8

18,961

0.422

0.57 (0.28, 1.18)

0.57 (0.28, 1.17)

0.59 (0.29, 1.22)

0.56 (0.27, 1.15)

 DCIS+Invasive

4683

20

24,228

0.825

1.10 (0.68, 1.78)

1.10 (0.68, 1.78)

1.13 (0.70, 1.84)

0.79 (0.44, 1.41)

≥50 years old

 Control group

15,660

212

75,174

2.820

1

1

1

1

 Pure DCIS

2347

24

11,114

2.159

0.77 (0.50, 1.17)

0.74 (0.49, 1.13)

0.72 (0.47, 1.10)

0.67 (0.44, 1.02)

 DCIS+Invasive

2873

27

14,010

1.927

0.68 (0.46, 1.02)

0.70 (0.47, 1.050

0.68 (0.46, 1.02)

0.49 (0.31, 0.75)

Mortality

< 50 years old

 Control group

25,560

142

130,304

1.090

1

1

1

1

 Pure DCIS

3837

28

18,983

1.475

1.26 (0.91, 2.04)

1.36 (0.91, 2.04)

1.42 (0.94, 2.23)

1.21 (0.80, 1.83)

 DCIS+Invasive

4683

60

24,494

2.470

2.26 (1.67, 3.06)

2.26 (1.67, 3.06)

2.32 (1.72, 3.15)

1.16 (0.79, 1.69)

≥50 years old

 Control group

15,660

285

75,690

3.765

1

1

1

1

 Pure DCIS

2347

40

11,166

3.582

0.95 (0.69, 1.33)

0.91 (0.66, 1.27)

0.92 (0.66, 1.28)

0.81 (0.58, 1.13)

 DCIS+Invasive

2873

70

14,063

4.978

1.32 (1.02, 1.71)

1.37 (1.60, 1.78)

1.40 (1.08, 1.82)

0.85 (0.63, 1.15)

  1. CI confidence interval, DCIS ductal carcinoma in situ, HR hazard ratio
  2. aModel 1 is crude
  3. bModel 2 is adjusted for age at diagnosis
  4. cModel 3 is adjusted for age at diagnosis, income, diabetes mellitus, hypertension, and dyslipidemia
  5. dModel 4 is adjusted for age at diagnosis, income, residence, diabetes mellitus, hypertension, dyslipidemia, and Charlson’s comorbidity index score
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BMC Cancer

ISSN: 1471-2407

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