Cardiovascular events and mortality in a population-based cohort initially diagnosed with ductal carcinoma in situ

Table 2 Risk of myocardial infarct, stroke and mortality in DCIS group compared to the control group

		Total N	Events (n)	Follow-up Duration (Person-Year)	Incidence rate per 1000	Model 1^a HR (95% CI)	Model 2^b HR (95% CI)	Model 3^c HR (95% CI)	Model 4^d HR (95% CI)
Myocardial Infarct	Control group	41,220	193	205,501	0.939	1	1	1	1
	DCIS group	13,740	41	68,411	0.599	0.64 (0.46, 0.90)	0.64 (0.46, 0.89)	0.63 (0.45, 0.89)	0.51 (0.36, 0.74)
	▪ Pure DCIS	6184	20	30,104	0.664	0.71 (0.45, 1.13)	0.69 (0.44, 1.10)	0.69 (0.43, 1.09)	0.63 (0.40, 1.01)
	▪ DCIS+Invasive	7556	21	38,307	0.548	0.58 (0.37, 0.91)	0.59 (0.38, 0.93)	0.59 (0.37, 0.92)	0.42 (0.26, 0.68)
Stroke	Control group	41,220	309	205,246	1.506	1	1	1	1
	DCIS group	13,740	79	68,315	1.156	0.77 (0.60, 0.98)	0.77 (0.60, 0.98)	0.76 (0.59, 0.97)	0.60 (0.46, 0.79)
	▪ Pure DCIS	6184	32	30,076	1.064	0.71 (0.50, 1.02)	0.69 (0.48, 0.99)	0.68 (0.47, 0.98)	0.63 (0.44, 0.91)
	▪ DCIS+Invasive	7556	47	38,239	1.229	0.82 (0.60, 1.11)	0.83 (0.61, 1.13)	0.82 (0.60, 1.12)	0.58 (0.41, 0.82)
Mortality	Control group	41,220	427	205,994	2.073	1	1	1	1
	DCIS group	13,740	198	68,505	2.890	1.40 (1.18, 1.65)	1.39 (1.18, 1.65)	1.42 (1.20, 1.68)	0.97 (0.80, 1.17)
	▪ Pure DCIS	6184	68	30,150	2.255	1.09 (0.85, 1.41)	1.07 (0.82, 1.38)	1.08 (0.84, 1.40)	0.94 (0.73, 1.22)
	▪ DCIS+Invasive	7556	130	38,355	3.389	1.63 (1.34, 1.98)	0.66 (1.36, 2.02)	1.70 (1.39, 2.07)	0.99 (0.78, 1.24)

CI confidence interval, DCIS ductal carcinoma in situ, HR hazard ratio
^aModel 1 is crude
^bModel 2 is adjusted for age at diagnosis
^cModel 3 is adjusted for age at diagnosis, income, diabetes mellitus, hypertension, and dyslipidemia
^dModel 4 is adjusted for age at diagnosis, income, residence, diabetes mellitus, hypertension, dyslipidemia, and Charlson’s comorbidity index score

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