Serum epidermal growth factor-like domain 7 serves as a novel diagnostic marker for early hepatocellular carcinoma

Table 3 Clinicopathological features for patients with chronic liver disease in Testing and Validation Cohort

Clinicopathological features	Variables	Testing Cohort (n = 300)	Validation Cohort (n = 120)
Etiology	HBV	246	93
	HCV	10	4
	Non-B-non-C	58	23
Liver cirrhosis	Presence	190	78
Liver cirrhosis	Absence	110	42
Serum AFP level	≥ 20 μg/L	119	50
Serum AFP level	< 20 μg/L	181	70
ALT [IU/mL, media (range)]	N.A.	55.3 (8.1–189.7)	52.8 (13.3–167.5)
AST [IU/mL, media (range)]	N.A.	49.4 (15.5–117.2)	51.6 (25.9–138.8)
Total bilirubin [μmol/L, media (range)]	N.A.	27.3 (15.1–87.9)	25.4 (13.2–83.1)
Child-Pugh Class	A	204	73
	B	85	43
	C	11	4

HBV with hepatitis B virus infection, HCV with hepatitis C virus infection, Non-B-non-C without hepatitis B or hepatitis C virus infection, AFP α-fetoprotein, ALT Alanine aminotransferase, AST Aspartate aminotransferase, N.A. not applicable

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