A novel immune-related gene pair prognostic signature for predicting overall survival in bladder cancer

BMC Cancer

Table 6 Gene sets enriched in the low risk phenotype via GO

Gene set name	NES	NOM p-val	FDR q-val
GO_T_CELL_CYTOKINE_PRODUCTION	−1.594	0.034	0.227
GO_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE	−1.721	0.036	0.195
GO_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE	−1.740	0.034	0.192
GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION	−1.747	0.028	0.188
GO_CD4_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT	−1.754	0.019	0.183
GO_CD8_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION	− 1.798	0.019	0.160
GO_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE	−1.807	0.024	0.161
GO_POSITIVE_REGULATION_OF_PROTEIN_DEACETYLATION	−1.836	0.006	0.146
GO_POSITIVE_REGULATION_OF_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR	−1.838	0.004	0.149
GO_MHC_PROTEIN_COMPLEX	−1.838	0.002	0.150
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION	−1.859	0.006	0.146
GO_FATTY_ACID_BETA_OXIDATION	−1.872	0.004	0.147
GO_T_CELL_SELECTION	−1.889	0.017	0.156
GO_IMMUNOGLOBULIN_PRODUCTION	−1.898	0.002	0.163
GO_CD4_POSITIVE_OR_CD8_POSITIVE_ALPHA_BETA_T_CELL_LINEAGE_COMMITMENT	−1.919	0.004	0.157
GO_T_CELL_RECEPTOR_SIGNALING_PATHWAY	−1.920	0.008	0.161
GO_FATTY_ACID_CATABOLIC_PROCESS	−1.936	0.004	0.168
GO_POSITIVE_T_CELL_SELECTION	−1.944	0.004	0.194
GO_T_CELL_RECEPTOR_COMPLEX	−1.972	0.002	0.260
GO_MHC_PROTEIN_BINDING	−1.994	0.006	0.369

Gene sets with NOM p-val < 0.05 and FDR q-val < 0.25 were considered significant
GO Gene Ontology, NES normalized enrichment score, NOM nominal, FDR false discovery rate

ISSN: 1471-2407