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Fig. 4 | BMC Cancer

Fig. 4

From: Inference of kinase-signaling networks in human myeloid cell line models by Phosphoproteomics using kinase activity enrichment analysis (KAEA)

Fig. 4

The phosphoproteome analysis of MOLM13 perturbed with Midostaurin. A Barplot represents the number of quantified PS in every replicate before imputation for MOLM13 exposed to control (CTRL, red) or 20 nM Midostaurin (DRG, green) conditions. B, C Inhibition of FLT3 downstream reference site, pSTAT5A/B Y694/Y699 as shown by WB and MS. The original western blots can be found in the additional file 2. D KAEA waterfall plot showing overactive (red) and underactive kinases (blue) after exposure of MOLM13 to Midostaurin. E STRING kinase-signaling network of significantly positive (red) and negative (blue) enriched kinases. The magenta edged kinases with asterisks (*) highlight experimentally validated targets of Midostaurin. TS: tumor suppressor

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BMC Cancer

ISSN: 1471-2407

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