Fig. 3

Identification of SASE in KIRC. a Heatmap of the SASEs between TSC group and USC group (|log2FC| ≥ 1, adjusted P < 0.05 and ΔPSI> 0.1). b-c Intersection of events and genes between KASEs and SASEs. d Circos plot of the annotation of intersected genes in (c) and their related splicing events. The outer circle is composed of the polyline that represents the number of splicing events generated by the intersected genes. The intermediate circle represents the group of splicing events, including events unique to KASEs, events unique to SASEs, events overlapped in KASEs and SASEs, and events that were not a significant different event. The inner circle represents the intersected genes in (c). The ribbons represent the 41 genes. e Correlation between mRNAsi and PSI values of SASE. f Correlation network of splicing factors and SASEs in KIRC. The splicing correlation network was built based on significant correlations between the PSI values of SASEs and the expression of splicing factors. A node represents an SASEs or a splicing factor, which is distinguished by color of the node. The color of lines represents splicing types