Elevated TYROBP expression predicts poor prognosis and high tumor immune infiltration in patients with low-grade glioma

Table 4 Gene enrichment analysis based on high and low TYROBP expression phenotype

Gene set name	NES	P.adjust	FDR
high expression
GO_NEUTROPHIL_CHEMOTAXIS	1.546	0.003	0.002
GO_MACROPHAGE_ACTIVATION	1.547	0.003	0.002
GO_REGULATION_OF_DENDRITIC_CELL_DIFFERENTIATION	1.595	0.012	0.009
GO_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION	1.542	0.003	0.002
GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION	1.507	0.003	0.002
KEGG_CHEMOKINE_SIGNALING_PATHWAY	1.394	0.004	0.004
KEGG_JAK_STAT_SIGNALING_PATHWAY	1.328	0.007	0.006
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY	1.369	0.038	0.033
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	1.435	0.004	0.004
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY	1.442	0.004	0.004
low expression
GO_GAMMA_AMINOBUTYRIC_ACID_SIGNALING_PATHWAY	−1.546	0.013	0.011
GO_NEUROTRANSMITTER_TRANSPORT	−1.611	0.004	0.004
GO_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY	−1.688	0.004	0.004
GO_GABA_GATED_CHLORIDE_ION_CHANNEL_ACTIVITY	−1.735	0.004	0.004
GO_VOLTAGE_GATED_CATION_CHANNEL_ACTIVITY	−1.698	0.004	0.004
KEGG_CALCIUM_SIGNALING_PATHWAY	−1.509	0.009	0.009
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	−1.644	0.009	0.009

NES: normalized enrichment score; P.adjust: adjust P value; FDR: false discovery rate
Gene sets with adjust p-value < 0.05 and FDR q-value < 0.05 are considered as significant

ISSN: 1471-2407