Fig. 6
Functional annotation of TYROBP in LGG. (A) GSEA results showing differential enrichment of GO terms as a function of TYROBP expression. Top 5 GO terms for TYROBPhigh - neutrophil chemotaxis, macrophage activation, regulation of dendritic cell differentiation, regulation of mononuclear cell migration and positive regulation of leukocyte proliferation. Top 5 GO terms for TYROBPlow - gamma aminobutyric acid signaling pathway, neurotransmitter transport, regulation of neuronal synaptic plasticity, GABA gated chloride ion channel activity and voltage gated cation channel activity. (B) GSEA results showing differential enrichment of KEGG pathways as a function of TYROBP. Top 5 KEGG pathways for TYROBPhigh - chemokine signaling pathway, JAK-STAT signaling pathway, NOD like receptor signaling pathway, natural killer cell mediated cytotoxicity and T cell receptor signaling pathway. Two KEGG pathways in TYROBPlow - calcium signaling pathway and neuroactive ligand receptor intersection. All results of GSEA were based on NES, adjusted P value and FDR value. GSEA, gene set enrichment analysis