Table 1 Correlations between immunophenotypic markers and comutations for NPM1mut AML
Association | Entire cohort | NPM1mut/FLT3-ITD(−) | NPM1mut/FLT3-ITD(+) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
χ2 P | OR (95% CI) | P | χ2 P | OR (95% CI) | P | χ2 P | OR (95% CI) | P | ||
CD34 (N = 202) | ×FLT3-ITD | < 0.001 | 5.29 (2.64–10.60) | < 0.001 | NA | NA | NA | NA | NA | NA |
×DNMT3A | 0.026 | NA | NA | NS | NA | NA | 0.028 | 2.60 (1.00–6.79) | 0.051 | |
×TET2/IDH1 | 0.001 | 0.26 (0.11–0.62) | 0.002 | NS | NA | NA | 0.005 | 0.21 (0.06–0.71) | 0.012 | |
CD7 (N = 186) | ×FLT3-ITD | < 0.001 | 3.47 (1.79–6.73) | < 0.001 | NA | NA | NA | NA | NA | NA |
×DNMT3A | < 0.001 | NA | NA | 0.008 | NA | NA | 0.007 | 3.30 (1.15–9.46) | 0.026 | |
×DNMT3A-R882 | < 0.001 | 3.59 (1.80–7.16) | < 0.001 | 0.002 | 3.93 (1.61–9.59) | 0.003 | 0.009 | NA | NA | |
×TET2/IDH1 | NS | 0.30 (0.14–0.62) | 0.001 | 0.048 | NA | NA | 0.001 | 0.18 (0.05–0.60) | 0.005 | |
HLA-DR (N = 200) | ×Ras pathways | < 0.001 | 4.05 (1.70–9.63) | 0.002 | 0.002 | 3.83 (1.40–10.46) | 0.009 | 0.055 | NA | NA |
×DNMT3A-R882 | < 0.001 | 13.41 (4.56–39.45) | < 0.001 | < 0.001 | 26.77 (3.44–208.46) | 0.002 | < 0.001 | 8.65 (2.28–32.89) | 0.002 | |
×TET2/IDH1 | 0.046 | NA | NA | NS | NA | NA | 0.002 | 0.26 (0.09–0.78) | 0.016 | |
MPO (N = 196) | ×KRAS | 0.003 | 0.18 (0.05–0.62) | 0.007 | 0.002 | 0.13 (0.03–0.56) | 0.006 | NS | NA | NA |
×DNMT3A | < 0.001 | 0.35 (0.17–0.70) | 0.003 | 0.003 | NA | NA | 0.071 | NA | NA | |
×DNMT3A-R882 | 0.001 | NA | NA | 0.002 | 0.27 (0.10–0.74) | 0.011 | NS | NA | NA | |
×TET2/IDH1 | 0.001 | 3.52 (1.48–8.38) | 0.004 | 0.040 | NA | NA | 0.021 | 4.32 (1.16–16.15) | 0.029 | |
APL-like (N = 198) | ×Ras pathways | < 0.001 | 0.22 (0.08–0.57) | 0.002 | 0.008 | 0.32 (0.11–0.96) | 0.041 | 0.025 | NA | NA |
×DNMT3A-R882 | < 0.001 | 0.02 (0.00–0.18) | < 0.001 | < 0.001 | NA | NA | < 0.001 | 0.04 (0.01–0.36) | 0.004 | |
×TET2/IDH1 | 0.008 | 2.26 (1.07–4.78) | 0.033 | NS | NA | NA | < 0.001 | 6.73 (1.83–24.78) | 0.004 | |