Table 1 Patient baseline and disease characteristics
Characteristic | Treatment Set N = 88 |
|---|---|
Age | |
Median (range), years | 61 (37–87) |
< 65 | 53 (60) |
≥ 65 | 35 (40) |
≥ 75 | 5 (6) |
Sex | |
Female | 46 (52) |
Male | 42 (48) |
Smoking status | |
Never | 55 (63) |
Ex-smoker | 27 (31) |
Current smoker | 6 (7) |
ECOG PS score | |
0 | 15 (17) |
1 | 71 (81) |
2 | 2 (2) |
Tumor histology | |
Predominantly adenocarcinoma | 87 (99) |
Predominantly squamous | 1 (1) |
Clinical stage at initial diagnosis | |
IA | 7 (8) |
IB | 4 (5) |
IIA | 1 (1) |
IIB | 1 (1) |
IIIA | 2 (2) |
IIIB | 3 (3) |
IV | 70 (80) |
Metastases | |
Any | 86 (98) |
Brain | 27 (31) |
EGFR mutation categories | |
Del19 | 51 (58) |
L858R | 27 (31) |
Exon 20 insertions | 3 (3) |
L861Q | 6 (7) |
G719X | 4 (5) |
T790M | 2 (2) |
S768I | 0 |
Other | 2 (2) |
EGFR mutation | |
Common | 72 (82) |
Uncommon | 16 (18) |
Any previous systemic chemotherapies | 30 (34) |