Table 4 Selection of stratified doses with highest probability of target attainment (PTA) compared to that of the body surface area (BSA)-based and flat doses of MTX administered as 24 h continuous infusion
BSA-based | Flat | Stratified | ||
|---|---|---|---|---|
< 25% (< 1.7m2) | 25–75% (1.7–2.12 m2) | > 75% (> 2.12 m2) | ||
500 mg/m2 | 850 mg | 775 mg | 850 mg | 975 mg |
1000 mg/m2 | 1700 mg | 1550 mg | 1700 mg | 1900 mg |
2000 mg/m2 | 3400 mg | 3000 mg | 3400 mg | 3800 mg |