Evaluation of body-surface-area adjusted dosing of high-dose methotrexate by population pharmacokinetics in a large cohort of cancer patients

Table 2 Population disease characteristics

Tumor type	n
Solid tumors
Sarcoma	4
Carcinoma	2
Hodgkin lymphoma	5
Non-Hodgkin lymphoma	9
Leukemia / very aggressive Non-Hodgkin lymphoma
Acute lymphoblastic leukemia	64
Acute myeloid leukemia	1
Others	43
Low aggressive Non-Hodgkin lymphoma	101

Diagnoses were defined as following ICD-10 codes
Sarcoma: C30.1, C34.1, C34.3, C34.8, C40.0, C40.2, C41.2, C41.3, C41.9
Carcinoma: C49.9, C58
Hodgkin lymphoma: C81.1, C81.2, C81.7, C81.9
Non-Hodgkin lymphoma: C71.0, C71.1, C71.2, C71.8, C78.2, C79.3, C79.5
Acute lymphoblastic leukemia: C91.00, C91.01, C91.50, C91.51, C91.80, C91.81
Acute myeloid leukemia: C92.00, C92.01, C94.70, C95.00
Others: C83.1, C83.7, C83.8, C84.4, C84.5, C86.2, C91.40, C91.60, C91.61
Low aggressive Non-Hodgkin lymphoma: C82.2, C82.4, C82.7, C82.9, C83.0, C83.3, C83.5, C85.1, C85.2, C85.7, C85.9, C91.10

ISSN: 1471-2407