Evaluation of body-surface-area adjusted dosing of high-dose methotrexate by population pharmacokinetics in a large cohort of cancer patients

Table 1 Population characteristics. Median and range for measured values are shown

Characteristics	Total n = 229	Females n = 83	Males n = 146
Age (years)	58 [19, 82]	66 [19, 77]	51 [19, 82]
Weight (kg)	78.4 [41.5, 227	70.2 [41.5, 96.5]	84.3 [50.0, 227]
Height (cm)	176 [154, 203]	167 [154, 180]	180 [162, 103]
Body surface area (m²)	1.96 [1.34, 3.42]	1.80 [1.34, 2.11]	2.06 [1.54, 3.42]
Body mass index (kg/m²)	25.4 [15.7, 66.3]	25.3 [15.7, 38.7]	26.0 [17.3, 66.3]
Serum creatinine (mg/dL)	0.74 [0.36, 1.66]	0.67 [0.38, 1.34]	0.84 [0.36, 1.66]
Total plasma bilirubin (mg/dL)	0.48 [0.09, 2.90]	0.45 [0.09, 1.60]	0.50 [0.09, 2.90]
Plasma γ-glutamyltransferase (mg/dL)	69.8 [14.0, 442]	67.2 [16.0, 442]	72.1 [14, 441]
Plasma urea (mg/dL)	32.0 [2.90, 949]	29.1 [2.90, 58.0]	47.0 [12.0, 949]
Absolute leucocyte count (×10⁹/L)	6.28 [0.05, 61.1]	5.77 [0.29, 33.29]	6.63 [0.05, 61.1]

Body surface area was computed using Du Bois Formula [46]
Normal levels Serum creatinine: females 0.5–0.9 mg/dL; males 0.5–1.1 mg/dL; total plasma bilirubin: 0–1.2 mg/dL; plasma γ-glutamyltransferase: females 0–40 mg/dL; males 0–60 mg/dL; plasma urea: 0–50 mg/dL; absolute leucocyte count: 4.4–11.3 × 10⁹/L; Missing data was interpolated (last observation carried forward/backward)

ISSN: 1471-2407