Associations between alcohol consumption and cardiovascular disease among long-term survivors of colorectal cancer: a population-based, retrospective cohort study

Table 3 Alcohol’s effects on CVD, IHD, and stroke risks among female long-term survivors of colorectal cancer

Outcome	0 g/day (n = 8084)	0.1–9.9 g/day (n = 606)	10–19.9 g/day (n = 95)	≥ 20 g/day (n = 94)	P for trend
CVD					0.011
Event (%)	322 (4.0)	16 (2.6)	4 (4.2)	8 (8.5)
Person-years	26,408	1905	299	287
HR (95% CI)	1.00 (Reference)	0.95 (0.57–1.58)	1.54 (0.56–4.23)	3.40 (1.63–7.12)
IHD					0.514
Event (%)	148 (1.8)	12 (1.7)^a		1 (1.1)
Person-years	26,831	2222		305
HR (95% CI)	1.00 (Reference)	1.42 (0.77–2.59)		0.82 (0.11–5.96)
Stroke					< 0.001
Event (%)	195 (2.4)	8 (1.1)^a		7 (7.4)
Person-years	26,757	2224		291
HR (95% CI)	1.00 (Reference)	0.67 (0.33–1.38)		4.52 (2.02–10.14)

HR calculated using Cox proportional hazards regression after adjustments for age, household income, body mass index, systolic blood pressure, fasting serum glucose, total cholesterol, smoking, physical activity, Charlson Comorbidity Index, history of chemotherapy, and history of radiotherapy
CVD cardiovascular disease, IHD ischemic heart disease, HR hazard ratio, CI confidence interval
^a0.1–9.9 g/day and 10–19.9 g/day groups were merged due to the limited number of events

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