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Table 4 Characteristics of studies about blood NO variation in lung cancer patients between pretreatment and posttreatment

From: Nitric oxide in occurrence, progress and therapy of lung Cancer: a systemic review and meta-analysis

Year

Author

Country

Age (Mean ± SD)

Sex (M/F)

Smoking status

Histology

Stage

Treatment

Follow up period

Blood NO (μmol/L)

Before therapy

After therapy

Mean ± SD

n

Mean ± SD

n

1997

Zhang

China

58.4a

13/7

NA

SCC, ADC, LCC, SCLC

advanced

chemo-therapy

1 week

51.2 ± 16.9

10

79.8 ± 21.3

10

1998

Yu

China

64.2a

28/18

NA

SCC, ADC

early + advanced

surgery

NA

7.51 ± 1.40

26

6.68 ± 1.19

26

chemo-therapy

NA

6.58 ± 1.30

15

5.43 ± 1.43

15

1999

Yu

China

49 士 3.8

14/4

NA

SCC, ADC

early + advanced

chemo-therapy /surgery

NA

9.91 ± 1.03

18

8.48 ± 1.06

18

2002

Li

China

64.3b (37–75)

53/31

NA

SCC, ADC

early + advanced

chemo-therapy

NA

64.6 ± 29.5

84

88.9 ± 39.4

84

2002

Wang

China

65.4a

35/13

NA

SCC, ADC, LCC

early + advanced

surgery

NA

7.124 ± 1.631

26

6.094 ± 0.917

26

2003

Liu

China

61.4 ± 11.3

30/6

NA

SCC, ADC

NA

surgery

10 days

8.72 ± 1.96

20

6.83 ± 1.75

20

2003

Zhao

China

51.8a

28/12

NA

NA

early

surgery

1 month

60.4 ± 27.2

40

37.8 ± 15.1

40

2005

Yin

China

57.04 ± 11.87

33/8

NA

SCC, ADC, SCLC

early + advanced

chemo-therapy

2 weeks

38.03 ± 36.59

40

29.33 ± 20.97

40

2005

Chen

China

NA

NA

NA

NA

early

surgery

3 months

30.4 ± 12.9

31

62.2 ± 15.1

30

2006

Li

China

57.8a

47/15

NA

SCC, ADC

early + advanced

surgery

21 days

86.7 ± 24.1

19

84.7 ± 18.4

19

chemo-therapy

21 days

89.4 ± 22.1

27

55.7 ± 16.7

27

2006

Colakogullari

Turkey

58.5 ± 10.6

25/6

NA

NSCLC, SCLC

advanced

chemo-therapy

2 days

93.0 ± 48.0

31

106.0 ± 49.0

16

2010

Srivastava

India

55b (30–88)

155 / 48

NA

mainly SCC, ADC, LCC

advanced

chemo-therapy

88 weeks

25.76 ± 4.54

203

32.81 ± 4.27

155

2015

Xu

China

36–80c

24/12

NA

SCC, ADC, LCC, SCLC

NA

chemo-therapy

NA

30.1 ± 11.7

36

62.0 ± 14.7

36

2017

Muto

Japan

65.3 ± 6.3

6/9

NA

ADC

advanced

chemo-therapy

> 30 months

62.7 ± 40.0

15

37.6 ± 27.5

15

2019

Feng

China

52.7 ± 4.6

28/15

NA

SCC, ADC

advanced

chemo-therapy

3 months

125.08 ± 14.89

43

89.77 ± 11.35

43

53.4 ± 3.6

26/18

NA

SCC, ADC

advanced

chemo-therapy + TCM

3 months

126.56 ± 14.57

44

78.12 ± 8.12

44

  1. Abbreviations: NA Not available, SCC Squamous cell carcinoma, ADC Adenocarcinoma, LCC Large cell carcinoma, NSCLC Non-small cell lung cancer, SCLC Small cell lung cancer
  2. aData presented as mean value
  3. bData presented as median (range)
  4. cData presented as range