Table 3 Cox proportional risk regression of BCSS among TNBC patients who underwent BCS or mastectomy
Variable | Group | Reference | Local treatment | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|---|---|
HR(95%CI) | P | HR(95%CI) | P | ||||
Totala |  | BCS + RT | Mastectomy alone | 1.90(1.67–2.15) | 0.000 | 1.49(1.31–1.70) | 0.000 |
|  | BCS + RT | Mastectomy+RT | 3.75(3.33–4.24) | 0.000 | 1.24(1.08–1.43) | 0.002 | |
|  | Mastectomy alone | Mastectomy+RT | 1.98(1.77–2.22) | 0.000 | 0.83(0.74–0.94) | 0.003 | |
Ageb | < 45 | BCS + RT | Mastectomy alone | 1.56(1.19–2.06) | 0.001 | 1.44(1.09–1.91) | 0.010 |
|  | BCS + RT | Mastectomy+RT | 3.10(2.38–4.05) | 0.000 | 1.24(0.93–1.65) | 0.135 | |
|  | Mastectomy alone | Mastectomy+RT | 1.99(1.61–2.44) | 0.000 | 0.86(0.69–1.07) | 0.186 | |
45 ~ 54 | BCS + RT | Mastectomy alone | 1.75(1.38–2.21) | 0.000 | 1.50(1.18–1.90) | 0.001 | |
|  | BCS + RT | Mastectomy+RT | 3.61(2.87–4.53) | 0.000 | 1.21(0.94–1.56) | 0.145 | |
|  | Mastectomy alone | Mastectomy+RT | 2.06(1.66–2.56) | 0.000 | 0.81(0.64–1.02) | 0.073 | |
55 ~ 64 | BCS + RT | Mastectomy alone | 1.74(1.37–2.21) | 0.000 | 1.35(1.05–1.73) | 0.018 | |
|  | BCS + RT | Mastectomy+RT | 3.87(3.09–4.85) | 0.000 | 1.24(0.95–1.62) | 0.112 | |
|  | Mastectomy alone | Mastectomy+RT | 2.22(1.75–2.81) | 0.000 | 0.92(0.71–1.19) | 0.522 | |
≥65 | BCS + RT | Mastectomy alone | 2.79(2.15–3.62) | 0.000 | 1.87(1.42–2.47) | 0.000 | |
|  | BCS + RT | Mastectomy+RT | 4.73(3.60–6.21) | 0.000 | 1.35(0.98–1.86) | 0.066 | |
|  | Mastectomy alone | Mastectomy+RT | 1.70(1.32–2.18) | 0.000 | 0.72(0.55–0.95) | 0.019 | |
Tumor sizec | T1 | BCS + RT | Mastectomy alone | 1.33(1.03–1.72) | 0.028 | 1.31(1.01–1.70) | 0.045 |
|  | BCS + RT | Mastectomy+RT | 3.67(2.74–4.91) | 0.000 | 1.40(1.00–1.96) | 0.048 | |
|  | Mastectomy alone | Mastectomy+RT | 2.75(2.01–3.77) | 0.000 | 1.07(0.76–1.52) | 0.699 | |
T2 | BCS + RT | Mastectomy alone | 1.29(1.08–1.53) | 0.004 | 1.35(1.13–1.60) | 0.001 | |
|  | BCS + RT | Mastectomy+RT | 2.19(1.84–2.61) | 0.000 | 1.24(1.02–1.50) | 0.029 | |
|  | Mastectomy alone | Mastectomy+RT | 1.71(1.44–2.03) | 0.000 | 0.92(0.76–1.11) | 0.374 | |
T3 | BCS + RT | Mastectomy alone | 2.41(1.63–3.54) | 0.000 | 2.00(1.35–2.97) | 0.001 | |
|  | BCS + RT | Mastectomy+RT | 2.19(1.51–3.17) | 0.000 | 1.58(1.08–2.31) | 0.018 | |
|  | Mastectomy alone | Mastectomy+RT | 0.91(0.72–1.15) | 0.431 | 0.79(0.62–1.00) | 0.054 | |
T4 | BCS + RT | Mastectomy alone | 2.91(1.52–5.59) | 0.001 | 2.62(1.31–5.26) | 0.007 | |
|  | BCS + RT | Mastectomy+RT | 1.92(1.01–3.65) | 0.046 | 1.52(0.77–3.02) | 0.231 | |
|  | Mastectomy alone | Mastectomy+RT | 0.66(0.51–0.86) | 0.002 | 0.58(0.44–0.76) | 0.000 | |
Lymph node statusd | N0 | BCS + RT | Mastectomy alone | 1.51(1.24–1.84) | 0.000 | 1.38(1.12–1.69) | 0.002 |
|  | BCS + RT | Mastectomy+RT | 2.81(2.13–3.69) | 0.000 | 1.63(1.19–2.24) | 0.002 | |
|  | Mastectomy alone | Mastectomy+RT | 1.86(1.41–2.45) | 0.000 | 1.19(0.88–1.61) | 0.268 | |
N1 | BCS + RT | Mastectomy alone | 1.87(1.52–2.30) | 0.000 | 1.64(1.32–2.03) | 0.000 | |
|  | BCS + RT | Mastectomy+RT | 1.71(1.40–2.10) | 0.000 | 1.31(1.05–1.62) | 0.017 | |
|  | Mastectomy alone | Mastectomy+RT | 0.92(0.76–1.10) | 0.359 | 0.80(0.66–0.96) | 0.018 | |
N2 | BCS + RT | Mastectomy alone | 1.67(1.19–2.35) | 0.003 | 1.30(0.91–1.85) | 0.156 | |
|  | BCS + RT | Mastectomy+RT | 1.33(0.99–1.79) | 0.058 | 1.05(0.77–1.44) | 0.753 | |
|  | Mastectomy alone | Mastectomy+RT | 0.80(0.61–1.04) | 0.096 | 0.81(0.62–1.06) | 0.132 | |
N3 | BCS + RT | Mastectomy alone | 2.71(1.81–4.07) | 0.000 | 2.07(1.34–3.19) | 0.001 | |
|  | BCS + RT | Mastectomy+RT | 1.86(1.28–2.72) | 0.001 | 1.44(0.96–2.16) | 0.077 | |
|  | Mastectomy alone | Mastectomy+RT | 0.69(0.53–0.89) | 0.005 | 0.70(0.53–0.91) | 0.008 | |