Table 2 Cox proportional risk regression analysis of Overall Survival among TNBC patients who underwent BCS or mastectomy
Variable | Group | Reference | Local treatment | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|---|---|
HR(95%CI) | P | HR(95%CI) | P | ||||
Total a |  | BCS + RT | Mastectomy alone | 1.94(1.73–2.18) | 0.000 | 1.57(1.40–1.77) | 0.000 |
|  | BCS + RT | Mastectomy+RT | 3.59(3.20–4.02) | 0.000 | 1.28(1.12–1.46) | 0.000 | |
|  | Mastectomy alone | Mastectomy+RT | 1.85(1.66–2.05) | 0.000 | 0.81(0.73–0.91) | 0.000 | |
Age b | < 45 | BCS + RT | Mastectomy alone | 1.57(1.21–2.05) | 0.001 | 1.47(1.12–1.92) | 0.005 |
|  | BCS + RT | Mastectomy+RT | 3.00(2.32–3.88) | 0.000 | 1.23(0.94–1.62) | 0.139 | |
|  | Mastectomy alone | Mastectomy+RT | 1.91(1.56–2.33) | 0.000 | 0.84(0.68–1.04) | 0.109 | |
45 ~ 54 | BCS + RT | Mastectomy alone | 1.78(1.42–2.22) | 0.000 | 1.51(1.20–1.91) | 0.000 | |
|  | BCS + RT | Mastectomy+RT | 3.63(2.92–4.52) | 0.000 | 1.25(0.98–1.60) | 0.072 | |
|  | Mastectomy alone | Mastectomy+RT | 2.05(1.67–2.51) | 0.000 | 0.83(0.66–1.03) | 0.095 | |
55 ~ 64 | BCS + RT | Mastectomy alone | 1.87(1.50–2.34) | 0.000 | 1.44(1.15–1.82) | 0.002 | |
|  | BCS + RT | Mastectomy+RT | 3.93(3.17–4.86) | 0.000 | 1.30(1.01–1.68) | 0.040 | |
|  | Mastectomy alone | Mastectomy+RT | 2.10(1.69–2.61) | 0.000 | 0.90(0.71–1.14) | 0.396 | |
≥65 | BCS + RT | Mastectomy alone | 2.82(2.25–3.52) | 0.000 | 1.99(1.57–2.52) | 0.000 | |
|  | BCS + RT | Mastectomy+RT | 4.13(3.25–5.25) | 0.000 | 1.38(1.04–1.82) | 0.027 | |
|  | Mastectomy alone | Mastectomy+RT | 1.47(1.17–1.83) | 0.001 | 0.69(0.54–0.88) | 0.003 | |
Tumor size c | T1 | BCS + RT | Mastectomy alone | 1.36(1.08–1.71) | 0.009 | 1.37(1.09–1.74) | 0.008 |
|  | BCS + RT | Mastectomy+RT | 3.54(2.71–4.62) | 0.000 | 1.49(1.10–2.02) | 0.011 | |
|  | Mastectomy alone | Mastectomy+RT | 2.60(1.96–3.46) | 0.000 | 1.08(0.79–1.49) | 0.615 | |
T2 | BCS + RT | Mastectomy alone | 1.36(1.16–1.60) | 0.000 | 1.44(1.22–1.69) | 0.000 | |
|  | BCS + RT | Mastectomy+RT | 2.20(1.87–2.59) | 0.000 | 1.27(1.06–1.53) | 0.008 | |
|  | Mastectomy alone | Mastectomy+RT | 1.62(1.38–1.90) | 0.000 | 0.88(0.74–1.05) | 0.170 | |
T3 | BCS + RT | Mastectomy alone | 2.61(1.81–3.77) | 0.000 | 2.21(1.52–3.22) | 0.000 | |
|  | BCS + RT | Mastectomy+RT | 2.15(1.51–3.07) | 0.000 | 1.61(1.12–2.31) | 0.011 | |
|  | Mastectomy alone | Mastectomy+RT | 0.82(0.66–1.02) | 0.082 | 0.73(0.58–0.91) | 0.005 | |
T4 | BCS + RT | Mastectomy alone | 2.69(1.48–4.89) | 0.001 | 2.34(1.24–4.41) | 0.009 | |
|  | BCS + RT | Mastectomy+RT | 1.73(0.96–3.12) | 0.068 | 1.36(0.73–2.54) | 0.334 | |
|  | Mastectomy alone | Mastectomy+RT | 0.64(0.50–0.83) | 0.001 | 0.58(0.45–0.75) | 0.000 | |
Lymph node status d | N0 | BCS + RT | Mastectomy alone | 1.53(1.28–1.83) | 0.000 | 1.44(1.20–1.73) | 0.000 |
|  | BCS + RT | Mastectomy+RT | 2.66(2.06–3.44) | 0.000 | 1.57(1.17–2.11) | 0.003 | |
|  | Mastectomy alone | Mastectomy+RT | 1.74(1.35–2.25) | 0.000 | 1.09(0.82–1.45) | 0.543 | |
N1 | BCS + RT | Mastectomy alone | 1.97(1.63–2.39) | 0.000 | 1.74(1.43–2.12) | 0.000 | |
|  | BCS + RT | Mastectomy+RT | 1.76(1.46–2.13) | 0.000 | 1.38(1.13–1.69) | 0.002 | |
|  | Mastectomy alone | Mastectomy+RT | 0.89(0.75–1.06) | 0.196 | 0.79(0.67–0.95) | 0.009 | |
N2 | BCS + RT | Mastectomy alone | 1.83(1.32–2.53) | 0.000 | 1.45(1.03–2.04) | 0.034 | |
|  | BCS + RT | Mastectomy+RT | 1.32(0.99–1.76) | 0.060 | 1.06(0.78–1.44) | 0.693 | |
|  | Mastectomy alone | Mastectomy+RT | 0.72(0.56–0.93) | 0.012 | 0.73(0.57–0.95) | 0.019 | |
N3 | BCS + RT | Mastectomy alone | 2.64(1.80–3.88) | 0.000 | 2.10(1.40–3.17) | 0.000 | |
|  | BCS + RT | Mastectomy+RT | 1.78(1.24–2.54) | 0.002 | 1.44(0.98–2.10) | 0.063 | |
|  | Mastectomy alone | Mastectomy+RT | 0.67(0.52–0.86) | 0.002 | 0.68(0.53–0.88) | 0.004 | |