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Table 2 Univariate and multivariate analyses for objective response rates (ORR)

From: Reductions in AFP and PIVKA-II can predict the efficiency of anti-PD-1 immunotherapy in HCC patients

Variables Univariate Multivariate
OR (95%CI) P value OR (95%CI) P value
Age, years   0.405   
  ≤ 50 1.0    
 >50 1.26 (0.73–2.16)    
Gender   0.128   
 Female 1.0    
 Male 2.0 (0.82–4.85)    
Vascular invasion   0.138   
 No 1.0    
 Yes 1.51 (0.88–2.59)    
Extrahepatic metastasis   0.002   0.112
 No 1.0   1.0  
 Yes 0.38 (0.21–0.69)   0.58 (0.30–1.14)  
ALBI grade   0.038   0.025
 I 1.0   1.0  
 II 0.55 (0.31–0.97)   0.49 (0.26–0.91)  
AFP reduction> 50%   <0.001   < 0.001
 No 1.0   1.0  
 Yes 5.15 (2.85–9.29)   3.36 (1.75–6.45)  
PIVKA-II reduction> 50%   <0.001   0.003
 No 1.0   1.0  
 Yes 4.43 (2.44–8.05)   2.72 (1.41–5.26)  
Baseline AFP level > 400 ng/ml   0.131   
 No 1.0    
 Yes 1.58 (0.87–2.84)    
Baseline PIVKA-II level > 400 mAU/ml   0.354   
 No 1.0    
 Yes 0.73 (0.37–1.43)