Table 1 Cumulative clinical data and mutational status for 19 patients with mucosal melanoma of female genital tract
From: Recurrent KRAS, KIT and SF3B1 mutations in melanoma of the female genital tract
| Â | Clinical information | Mutational status | CD117 expression | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patients | Tumor location | Age at diagnosis | Clinical stage | histological subtype | SF3B1 | KIT | PDGFRA | BRAF | NRAS | KRAS | NF1 | |
P01 | vagina | 56 | I | spindle | – | – | – | – | – | – | – |  |
P02 | vagina | 40 | II | mixed type | – | – | – | – | – | – | – |  |
P03 | vulva | 50 | III | mixed type | – | – | – | – | p.Q61 * | – | – |  |
P04 | vagina | 53 | II | epithelioid | – | p.S476N p.G498V | – | – | – | – | – | + |
P05 | vulva | 53 | I | epithelioid | – | p.L640P | – | – | – | – | – | + |
P06 | vagina | 77 | II | epithelioid | – | – | – | – | – | – | – |  |
P07 | cervix | 48 | I | epithelioid | – | – | – | – | – | – | – |  |
P08 | vagina | 84 | II | epithelioid | – | – | – | – | – | – | – |  |
P09 | vagina | 52 | II | epithelioid | – | p.D810H | – | – | – | p.G13D | – | + |
P10 | cervix | 42 | IV | spindle | – | – | – | – | – | p.G13D | – |  |
P11 | vulva | 59 | II | epithelioid | p.R625H | – | – | – | – | p.G13D | – |  |
P12 | cervix | 55 | IV | epithelioid | – | – | – | – | – | p.G12D | – | + |
P13 | vulva | 74 | IV | mixed type | – | – | – | – | – | – | – |  |
P14 | vulva | 72 | IV | spindle | p.R625H | – | – | – | – | – | – |  |
P15 | vagina | 56 | IV | epithelioid | – | – | – | – | – | p.G12D | – |  |
P16 | cervix | 42 | II | spindle | – | – | – | – | – | – | – |  |
P17 | cervix | 34 | III | mixed type | – | – | – | – | – | – | – |  |
P18 | vagina | 52 | II | epithelioid | p.R625H | p.V852A | – | – | – | – | – | + |
P 19 | cervix | 54 | IV | epithelioid | – | – | – | – | – | p.G13D | – | + |