Fig. 1From: Recurrent KRAS, KIT and SF3B1 mutations in melanoma of the female genital tractRepresentative hematoxylin and eosin staining and immunostaining of mucosal melanoma of the female genital tract. Microscopic examination revealed that the tumor cells were distributed in solid islets, nests, or band-like formations. Tumor cells were polygonal (A), epithelioid (B), or spindle in shape (C) (× 200 magnification). Immunohistochemical analysis revealed that CK expression was negative in most cases, but weakly focally positive in three of the 19 cases (D) (× 200 magnification). Tumor cells were strongly positive for Melan-A (E), HMB45 (F), S100 (G) and SOX-10 (H) protein in vulvar malignant melanomas (× 200 magnification)Back to article page