Table 2 Demographic and cancer-related risk factors for chest wall abnormalities in Swiss childhood cancer survivors
Total N = 2382 | Chest wall abnormalities (n = 48) | |||||
|---|---|---|---|---|---|---|
ORcrudea | (95%CI) | Pb | ORadjc | (95%CI) | Pc | |
Sex | 0.059 | 0.062 | ||||
Female | Ref. | Ref. | ||||
Male | 1.8 | (1.0–3.2) | 1.8 | (1.0–3.3) | ||
Age at diagnosis (years) | 0.125 | 0.017 | ||||
0–5 | Ref. | Ref. | ||||
6–10 | 0.7 | (0.3–1.8) | 0.5 | (0.2–1.2) | ||
11–15 | 1.2 | (0.6–2.5) | 0.7 | (0.3–1.6) | ||
16–20 | 2.4 | (1.1–5.3) | 2.5 | (1.0–6.1) | ||
Year of diagnosis | 0.768 | 0.602 | ||||
1976–1990 | Ref. | Ref. | ||||
1991–2005 | 0.9 | (0.5–1.7) | 0.8 | (0.5–1.6) | ||
Diagnosis | < 0.001 | < 0.001 | ||||
I: Leukemia | Ref. | Ref. | ||||
II: Lymphoma | 6.0 | (2.2–16.4) | 3.8 | (1.2–11.4) | ||
III: CNS tumor | 6.0 | (2.1–17.0) | 9.5 | (3.0–30.1) | ||
IV–XII: Other tumors | 2.6 | (0.9–7.3) | 2.1 | (0.7–6.1) | ||
Thoracic radiotherapy d | < 0.001 | 0.058 | ||||
No | Ref. | Ref. | ||||
Yes | 3.9 | (2.1–7.1) | 2.0 | (1.0–4.2) | ||
Surgery to the chest e | 0.002 | 0.004 | ||||
No | Ref. | Ref. | ||||
Yes | 4.5 | (2.0–10.4) | 4.5 | (1.8–11.5) | ||
Any chemotherapy | 0.348 | 0.029 | ||||
No | Ref. | Ref. | ||||
Yes | 1.5 | (0.6–3.5) | 2.9 | (1.0–8.1) | ||