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Table 3 Univariable and multivariable analyses of median time from diagnosis to first treatment (surgery, radiotherapy, systemic anticancer treatment or any treatment) among colorectal cancer patients diagnosed in 2015–2016 in Norway

From: Factors associated with emergency-onset diagnosis, time to treatment and type of treatment in colorectal cancer patients in Norway

 

Surgery

Radiotherapy

Systemic Anticancer Treatment

Any

 

Univariate

Multivariate

Univariate

Multivariate

Univariate

Multivariate

Univariate

Multivariate

 

Coeff (95%CI)

Coeff (95%CI)

Coeff (95%CI)

Coeff (95%CI)

Coeff (95%CI)

Coeff (95%CI)

Coeff (95%CI)

Coeff (95%CI)

Year of diagnosis

 2015

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

 2016

1.00 [−0.06,2.06]

0.13 [− 0.66,0.92]

− 2.00 [−3.88,-0.12]

−2.00 [−3.82,-0.18]

3.00 [0.28,5.72]

2.88 [− 0.04,5.79]

0.00 [− 0.80,0.80]

0.29 [− 0.43,1.00]

 p-value

0.065

0.750

0.037

0.032

0.030

0.053

1.00

0.431

Age group

 18–49

−5.00 [−7.82,-2.18]

−2.79 [−4.88,-0.71]

−3.00 [−6.83,0.83]

−3.00 [−6.79,0.79]

−2.00 [− 7.95,3.95]

−1.13 [−6.98,4.73]

−5.00 [− 7.12,-2.88]

−2.57 [− 4.35,-0.80]

 50–59

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

 60–69

1.00 [−1.00,3.00]

1.08 [−0.40,2.56]

0.00 [−2.64,2.64]

2.00 [− 0.68,4.68]

2.00 [− 2.08,6.08]

2.87 [− 1.13,6.88]

−1.00 [− 2.49,0.49]

1.43 [0.17,2.68]

 70–79

1.00 [− 0.92,2.92]

1.90 [0.42,3.37]

1.00 [−1.80,3.80]

2.00 [− 1.00,5.00]

5.00 [0.76,9.24]

5.00 [0.64,9.36]

−1.00 [− 2.45,0.45]

2.43 [1.16,3.70]

 80–89

1.00 [−1.03,3.03]

2.56 [0.99,4.14]

0.00 [−3.23,3.23]

3.00 [−0.43,6.43]

3.00 [− 3.84,9.84]

2.88 [− 3.96,9.71]

−3.00 [− 4.56,-1.44]

3.00 [1.61,4.39]

 90+

− 4.00 [−7.69,-0.31]

1.33 [− 1.45,4.12]

1.00 [−5.25,7.25]

−1.00 [− 7.37,5.37]

− 7.00 [− 10.02,-3.98]

1.00 [− 1.59,3.59]

 p-value

< 0.001

< 0.001

0.469

0.064

0.066

0.131

< 0.001

< 0.001

Sex

 Female

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

 Male

3.00 [1.94,4.06]

0.69 [−0.12,1.50]

−1.00 [−2.96,0.96]

− 1.00 [− 2.87,0.87]

1.00 [− 1.69,3.69]

0.25 [− 2.67,3.17]

2.00 [1.09,2.91]

0.71 [− 0.02,1.44]

p-value

< 0.001

0.094

0.316

0.295

0.466

0.867

< 0.001

0.055

Stage

        

 Localised

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

 Regional

1.00 [−0.16,2.16]

2.44 [1.50,3.38]

1.00 [−2.66,4.66]

1.50 [−2.25,5.25]

−15.00 [− 31.92,1.92]

− 16.13 [− 33.52,1.27]

2.00 [0.81,3.19]

2.29 [1.38,3.20]

 Metastasis

− 3.00 [−4.67,-1.33]

0.59 [− 0.76,1.94]

3.00 [− 1.05,7.05]

4.50 [0.39,8.61]

−16.00 [− 32.46,0.46]

−17.63 [− 34.57,-0.68]

2.00 [0.51,3.49]

0.57 [− 0.67,1.81]

 Unknown

− 16.00 [− 23.61,-8.39]

− 0.90 [−6.84,5.05]

2.00 [− 2.12,6.12]

4.00 [− 0.19,8.19]

−15.00 [− 31.62,1.62]

− 15.38 [− 32.52,1.77]

12.00 [9.40,14.60]

1.57 [− 0.60,3.74]

p-value

< 0.001

< 0.001

0.307

0.022

0.268

0.132

< 0.001

< 0.001

Marital status

 Single

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

 Married

1.00 [0.05,1.95]

−0.56 [− 1.40,0.27]

−2.00 [−3.68,-0.32]

− 1.00 [− 2.90,0.90]

−3.00 [−6.19,0.19]

−3.37 [− 6.34,-0.41]

1.00 [0.08,1.92]

−0.86 [− 1.61,-0.11]

 p-value

0.040

0.185

0.020

0.303

0.066

0.026

0.034

0.025

Income

        

 Low

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

 Intermediate

2.00 [0.71,3.29]

0.82 [−0.38,2.02]

3.00 [−0.17,6.17]

1.00 [−1.89,3.89]

−1.00 [− 5.54,3.54]

− 0.50 [− 5.17,4.17]

2.00 [0.82,3.18]

0.86 [− 0.24,1.95]

 High

1.00 [− 0.47,2.47]

0.28 [− 1.15,1.71]

2.00 [− 1.47,5.47]

0.00 [− 3.33,3.33]

−3.00 [− 7.77,1.77]

− 3.25 [− 8.32,1.82]

1.00 [− 0.32,2.32]

0.00 [− 1.29,1.29]

 p-value

0.004

0.296

0.163

0.611

0.312

0.217

0.001

0.087

Region

 Southern and Eastern Norway

0.75 [−0.01,1.51]

0.13 [− 0.48,0.73]

5.25 [3.91,6.59]

5.88 [4.48,7.27]

1.75 [−0.88,4.38]

1.16 [− 1.16,3.47]

0.50 [− 0.16,1.16]

0.82 [0.27,1.37]

 Western Norway

−0.25 [−1.22,0.72]

− 0.54 [− 1.32,0.24]

−0.75 [− 2.38,0.88]

−1.13 [− 2.82,0.57]

−4.25 [− 7.25,-1.25]

−3.22 [− 5.86,-0.58]

−0.50 [− 1.34,0.34]

−0.75 [− 1.44,-0.06]

 Central Norway

−1.25 [− 2.32,-0.18]

−0.74 [− 1.60,0.12]

−5.75 [− 7.56,-3.94]

−5.63 [− 7.49,-3.76]

−2.25 [− 6.07,1.57]

−3.22 [− 6.63,0.19]

− 1.50 [− 2.44,-0.56]

−1.32 [− 2.10,-0.55]

 Northern Norway

0.75 [−0.49,1.99]

1.15 [0.15,2.15]

1.25 [−0.72,3.22]

0.88 [−1.18,2.93]

4.75 [0.08,9.42]

5.28 [1.14,9.43]

1.50 [0.42,2.58]

1.25 [0.35,2.15]

 p-value

0.032

0.071

< 0.001

< 0.001

0.004

0.005

0.001

< 0.001

Emergency Presentation

 0

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

 1

− 12.00 [− 13.13,-10.87]

−7.00 [− 7.95,-6.05]

−2.00 [− 4.49,0.49]

−3.00 [−5.69,-0.31]

−6.00 [− 8.92,-3.08]

− 5.75 [− 8.88,-2.62]

− 10.00 [− 10.84,-9.16]

−7.00 [− 7.86,-6.14]

 p-value

< 0.001

< 0.001

0.116

0.029

< 0.001

< 0.001

< 0.001

< 0.001

Comorbidity

 No admissions

6.00 [3.48,8.52]

4.67 [2.58,6.76]

3.00 [− 1.44,7.44]

8.00 [3.55,12.45]

5.00 [−1.14,11.14]

5.63 [−0.98,12.23]

7.00 [4.50,9.50]

4.29 [2.44,6.13]

 0

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

 1–2

−1.00 [−2.19,0.19]

−0.03 [− 1.03,0.98]

−1.00 [−3.54,1.54]

− 0.50 [− 3.14,2.14]

1.00 [− 2.71,4.71]

2.00 [− 2.03,6.03]

−1.00 [− 2.22,0.22]

−0.29 [− 1.21,0.63]

 3+

1.00 [− 1.60,3.60]

1.97 [− 0.20,4.15]

0.00 [−5.91,5.91]

− 2.00 [−7.97,3.97]

9.00 [−6.83,24.83]

7.13 [−9.75,24.00]

1.00 [− 1.78,3.78]

1.71 [− 0.35,3.78]

 p-value

< 0.001

< 0.001

0.464

0.004

0.281

0.258

< 0.001

< 0.001

Cancer type

 Rectum

0.00 (ref)

0.00 (ref)

  

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

 Colon

−10.00 [−10.97,-9.03]

−8.54 [−9.50,-7.57]

  

−3.00 [−5.69,-0.31]

−1.87 [− 5.03,1.28]

−13.00 [− 13.66,-12.34]

−7.43 [− 8.32,-6.53]

 p-value

< 0.001

< 0.001

  

0.029

0.243

< 0.001

< 0.001

CPP

 0

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

0.00 (ref)

 1

17.00 [15.85,18.15]

9.77 [8.69,10.85]

0.00 [−4.13,4.13]

−3.00 [−7.31,1.31]

5.00 [1.61,8.39]

2.12 [−1.65,5.90]

17.00 [15.87,18.13]

9.00 [8.00,10.00]

 p-value

< 0.001

< 0.001

1.00

0.172

0.004

0.269

< 0.001

< 0.001

Treatment

 Surgery

      

0.00 (ref)

0.00 (ref)

 Radiotherapy

      

17.00 [15.46,18.54]

9.14 [7.66,10.62]

 Chemotherapy

      

9.00 [7.50,10.50]

9.86 [8.38,11.34]

 p-value

      

< 0.001

< 0.001