Surgery | Radiotherapy | Systemic Anticancer Treatment | Any | |||||
---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | |
Coeff (95%CI) | Coeff (95%CI) | Coeff (95%CI) | Coeff (95%CI) | Coeff (95%CI) | Coeff (95%CI) | Coeff (95%CI) | Coeff (95%CI) | |
Year of diagnosis | ||||||||
2015 | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) |
2016 | 1.00 [−0.06,2.06] | 0.13 [− 0.66,0.92] | − 2.00 [−3.88,-0.12] | −2.00 [−3.82,-0.18] | 3.00 [0.28,5.72] | 2.88 [− 0.04,5.79] | 0.00 [− 0.80,0.80] | 0.29 [− 0.43,1.00] |
p-value | 0.065 | 0.750 | 0.037 | 0.032 | 0.030 | 0.053 | 1.00 | 0.431 |
Age group | ||||||||
18–49 | −5.00 [−7.82,-2.18] | −2.79 [−4.88,-0.71] | −3.00 [−6.83,0.83] | −3.00 [−6.79,0.79] | −2.00 [− 7.95,3.95] | −1.13 [−6.98,4.73] | −5.00 [− 7.12,-2.88] | −2.57 [− 4.35,-0.80] |
50–59 | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) |
60–69 | 1.00 [−1.00,3.00] | 1.08 [−0.40,2.56] | 0.00 [−2.64,2.64] | 2.00 [− 0.68,4.68] | 2.00 [− 2.08,6.08] | 2.87 [− 1.13,6.88] | −1.00 [− 2.49,0.49] | 1.43 [0.17,2.68] |
70–79 | 1.00 [− 0.92,2.92] | 1.90 [0.42,3.37] | 1.00 [−1.80,3.80] | 2.00 [− 1.00,5.00] | 5.00 [0.76,9.24] | 5.00 [0.64,9.36] | −1.00 [− 2.45,0.45] | 2.43 [1.16,3.70] |
80–89 | 1.00 [−1.03,3.03] | 2.56 [0.99,4.14] | 0.00 [−3.23,3.23] | 3.00 [−0.43,6.43] | 3.00 [− 3.84,9.84] | 2.88 [− 3.96,9.71] | −3.00 [− 4.56,-1.44] | 3.00 [1.61,4.39] |
90+ | − 4.00 [−7.69,-0.31] | 1.33 [− 1.45,4.12] | 1.00 [−5.25,7.25] | −1.00 [− 7.37,5.37] | – | – | − 7.00 [− 10.02,-3.98] | 1.00 [− 1.59,3.59] |
p-value | < 0.001 | < 0.001 | 0.469 | 0.064 | 0.066 | 0.131 | < 0.001 | < 0.001 |
Sex | ||||||||
Female | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) |
Male | 3.00 [1.94,4.06] | 0.69 [−0.12,1.50] | −1.00 [−2.96,0.96] | − 1.00 [− 2.87,0.87] | 1.00 [− 1.69,3.69] | 0.25 [− 2.67,3.17] | 2.00 [1.09,2.91] | 0.71 [− 0.02,1.44] |
p-value | < 0.001 | 0.094 | 0.316 | 0.295 | 0.466 | 0.867 | < 0.001 | 0.055 |
Stage | ||||||||
Localised | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) |
Regional | 1.00 [−0.16,2.16] | 2.44 [1.50,3.38] | 1.00 [−2.66,4.66] | 1.50 [−2.25,5.25] | −15.00 [− 31.92,1.92] | − 16.13 [− 33.52,1.27] | 2.00 [0.81,3.19] | 2.29 [1.38,3.20] |
Metastasis | − 3.00 [−4.67,-1.33] | 0.59 [− 0.76,1.94] | 3.00 [− 1.05,7.05] | 4.50 [0.39,8.61] | −16.00 [− 32.46,0.46] | −17.63 [− 34.57,-0.68] | 2.00 [0.51,3.49] | 0.57 [− 0.67,1.81] |
Unknown | − 16.00 [− 23.61,-8.39] | − 0.90 [−6.84,5.05] | 2.00 [− 2.12,6.12] | 4.00 [− 0.19,8.19] | −15.00 [− 31.62,1.62] | − 15.38 [− 32.52,1.77] | 12.00 [9.40,14.60] | 1.57 [− 0.60,3.74] |
p-value | < 0.001 | < 0.001 | 0.307 | 0.022 | 0.268 | 0.132 | < 0.001 | < 0.001 |
Marital status | ||||||||
Single | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) |
Married | 1.00 [0.05,1.95] | −0.56 [− 1.40,0.27] | −2.00 [−3.68,-0.32] | − 1.00 [− 2.90,0.90] | −3.00 [−6.19,0.19] | −3.37 [− 6.34,-0.41] | 1.00 [0.08,1.92] | −0.86 [− 1.61,-0.11] |
p-value | 0.040 | 0.185 | 0.020 | 0.303 | 0.066 | 0.026 | 0.034 | 0.025 |
Income | ||||||||
Low | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) |
Intermediate | 2.00 [0.71,3.29] | 0.82 [−0.38,2.02] | 3.00 [−0.17,6.17] | 1.00 [−1.89,3.89] | −1.00 [− 5.54,3.54] | − 0.50 [− 5.17,4.17] | 2.00 [0.82,3.18] | 0.86 [− 0.24,1.95] |
High | 1.00 [− 0.47,2.47] | 0.28 [− 1.15,1.71] | 2.00 [− 1.47,5.47] | 0.00 [− 3.33,3.33] | −3.00 [− 7.77,1.77] | − 3.25 [− 8.32,1.82] | 1.00 [− 0.32,2.32] | 0.00 [− 1.29,1.29] |
p-value | 0.004 | 0.296 | 0.163 | 0.611 | 0.312 | 0.217 | 0.001 | 0.087 |
Region | ||||||||
Southern and Eastern Norway | 0.75 [−0.01,1.51] | 0.13 [− 0.48,0.73] | 5.25 [3.91,6.59] | 5.88 [4.48,7.27] | 1.75 [−0.88,4.38] | 1.16 [− 1.16,3.47] | 0.50 [− 0.16,1.16] | 0.82 [0.27,1.37] |
Western Norway | −0.25 [−1.22,0.72] | − 0.54 [− 1.32,0.24] | −0.75 [− 2.38,0.88] | −1.13 [− 2.82,0.57] | −4.25 [− 7.25,-1.25] | −3.22 [− 5.86,-0.58] | −0.50 [− 1.34,0.34] | −0.75 [− 1.44,-0.06] |
Central Norway | −1.25 [− 2.32,-0.18] | −0.74 [− 1.60,0.12] | −5.75 [− 7.56,-3.94] | −5.63 [− 7.49,-3.76] | −2.25 [− 6.07,1.57] | −3.22 [− 6.63,0.19] | − 1.50 [− 2.44,-0.56] | −1.32 [− 2.10,-0.55] |
Northern Norway | 0.75 [−0.49,1.99] | 1.15 [0.15,2.15] | 1.25 [−0.72,3.22] | 0.88 [−1.18,2.93] | 4.75 [0.08,9.42] | 5.28 [1.14,9.43] | 1.50 [0.42,2.58] | 1.25 [0.35,2.15] |
p-value | 0.032 | 0.071 | < 0.001 | < 0.001 | 0.004 | 0.005 | 0.001 | < 0.001 |
Emergency Presentation | ||||||||
0 | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) |
1 | − 12.00 [− 13.13,-10.87] | −7.00 [− 7.95,-6.05] | −2.00 [− 4.49,0.49] | −3.00 [−5.69,-0.31] | −6.00 [− 8.92,-3.08] | − 5.75 [− 8.88,-2.62] | − 10.00 [− 10.84,-9.16] | −7.00 [− 7.86,-6.14] |
p-value | < 0.001 | < 0.001 | 0.116 | 0.029 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Comorbidity | ||||||||
No admissions | 6.00 [3.48,8.52] | 4.67 [2.58,6.76] | 3.00 [− 1.44,7.44] | 8.00 [3.55,12.45] | 5.00 [−1.14,11.14] | 5.63 [−0.98,12.23] | 7.00 [4.50,9.50] | 4.29 [2.44,6.13] |
0 | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) |
1–2 | −1.00 [−2.19,0.19] | −0.03 [− 1.03,0.98] | −1.00 [−3.54,1.54] | − 0.50 [− 3.14,2.14] | 1.00 [− 2.71,4.71] | 2.00 [− 2.03,6.03] | −1.00 [− 2.22,0.22] | −0.29 [− 1.21,0.63] |
3+ | 1.00 [− 1.60,3.60] | 1.97 [− 0.20,4.15] | 0.00 [−5.91,5.91] | − 2.00 [−7.97,3.97] | 9.00 [−6.83,24.83] | 7.13 [−9.75,24.00] | 1.00 [− 1.78,3.78] | 1.71 [− 0.35,3.78] |
p-value | < 0.001 | < 0.001 | 0.464 | 0.004 | 0.281 | 0.258 | < 0.001 | < 0.001 |
Cancer type | ||||||||
Rectum | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | ||
Colon | −10.00 [−10.97,-9.03] | −8.54 [−9.50,-7.57] | −3.00 [−5.69,-0.31] | −1.87 [− 5.03,1.28] | −13.00 [− 13.66,-12.34] | −7.43 [− 8.32,-6.53] | ||
p-value | < 0.001 | < 0.001 | 0.029 | 0.243 | < 0.001 | < 0.001 | ||
CPP | ||||||||
0 | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) | 0.00 (ref) |
1 | 17.00 [15.85,18.15] | 9.77 [8.69,10.85] | 0.00 [−4.13,4.13] | −3.00 [−7.31,1.31] | 5.00 [1.61,8.39] | 2.12 [−1.65,5.90] | 17.00 [15.87,18.13] | 9.00 [8.00,10.00] |
p-value | < 0.001 | < 0.001 | 1.00 | 0.172 | 0.004 | 0.269 | < 0.001 | < 0.001 |
Treatment | ||||||||
Surgery | 0.00 (ref) | 0.00 (ref) | ||||||
Radiotherapy | 17.00 [15.46,18.54] | 9.14 [7.66,10.62] | ||||||
Chemotherapy | 9.00 [7.50,10.50] | 9.86 [8.38,11.34] | ||||||
p-value | < 0.001 | < 0.001 |