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Table 2 Univariate Cox Proportional Hazard Analysis of Prediction of TTP in Patients Stratified by NEL Type and CE Evolution Pattern

From: Refinement of response assessment in neuro-oncology (RANO) using non-enhancing lesion type and contrast enhancement evolution pattern in IDH wild-type glioblastomas

Entire Patients (n = 86)

Hazard Ratio

95% CI

P

NEL type

 Tumor-dominant

2.03

1.24–3.32

.005

 Edema-dominant

1

  

CE evolution pattern

 Enlarging residual CE (pattern 4)

4.33

2.02–9.28

<.001

 New measurable CE (pattern 3)

3.00

1.63–5.54

<.001

 Stable or responding residual CE (pattern 2)

2.44

0.80–7.28

.117

 New non-measurable CE (pattern 1)

1

  

Patients with edema-dominant NEL (n = 41)

 Enlarging residual CE (pattern 4)

6.92

1.71–27.93

.007

 New measurable CE (pattern 3)

5.36

2.10–13.66

<.001

 Stable or responding residual CE (pattern 2)

2.63

0.31–21.98

.372

 New non-measurable CE (pattern 1)

1

  
  1. TTP time to progression, NEL non-enhancing lesion, CE contrast enhancement, CI confidence interval