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Table 1 Clinicopathologic characteristics of study participants

From: Morphologic and molecular correlates of EZH2 as a predictor of platinum resistance in high-grade ovarian serous carcinoma

 

Overalla

Response to platinum-based therapy

Resistant

Sensitive

P-valueb

N

79

19

59

 

Age at diagnosis, mean (SD)

61.4 (11.1)

62.0 (12.4)

60.9 (10.6)

0.71

Stage, n (%)

 I,II

8 (10)

1 (5)

7 (12)

0.41

 III,IV

71 (90)

18 (95)

52 (88)

 

Debulking status, n (%)

 Suboptimal (Residual disease > 1 cm)

18 (24)

5 (26)

12 (21)

0.66

 Optimal (NED or residual disease < 1 cm)

58 (76)

14 (74)

44 (79)

 

Lymphovascular Invasion, n (%)

 Yes

62 (78)

15 (79)

46 (78)

0.93

 No

17 (22)

4 (21)

13 (22)

 

Cystic Component, n (%)

 Yes

54 (69)

13 (72)

40 (68)

0.72

 No

24 (31)

5 (28)

19 (32)

 

STIC, n (%)

 Yes

20 (28)

4 (22)

16 (31)

0.49

 No

51 (72)

14 (78)

36 (69)

 

TIL, n (%)

 Yes

32 (41)

10 (56)

22 (37)

0.17

 No

46 (59)

8 (44)

37 (63)

 

Vital Status, n (%)

 Alive

24 (31)

3 (16)

21 (36)

0.10

 Died

54 (69)

16 (84)

38 (64)

 

Months of follow-up, mean (SD)

60 (33)

36 (32)

58 (31)

0.008

  1. SD standard deviation, STIC serous tubal intraepithelial carcinoma, TIL tumor infiltrating lymphocytes, NED no evidence of disease
  2. aThe total N for some variables does not total to 79 due to missing data
  3. bStatistical significance testing was performed using the chi-square test for categorical variables and t-test for continuous variables